发明申请
US20070232690A1 Composition for inducing differentiation of leukemic cells and application thereof
审中-公开
用于诱导白血病细胞分化的组合物及其应用
- 专利标题: Composition for inducing differentiation of leukemic cells and application thereof
- 专利标题(中): 用于诱导白血病细胞分化的组合物及其应用
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申请号: US11391581申请日: 2006-03-28
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公开(公告)号: US20070232690A1公开(公告)日: 2007-10-04
- 发明人: Yu-Jen Chen , Hui-Fen Liao , Yueh-Hsiung Kuo
- 申请人: Yu-Jen Chen , Hui-Fen Liao , Yueh-Hsiung Kuo
- 申请人地址: TW Taipei
- 专利权人: Mackay Memorial Hospital
- 当前专利权人: Mackay Memorial Hospital
- 当前专利权人地址: TW Taipei
- 主分类号: A61K31/343
- IPC分类号: A61K31/343
摘要:
Disclosed is a medical composition for inducing differentiation of leukemic cells, which can induce leukemic cells to differentiate into monocytes and macrophages, and block the abnormal proliferation of leukemic cells through a PKC-independent pathway. In addition, the medical composition cans also downregulate c-myc gene expression in the leukemic cells, and upnregulate c-fms, c-fos and c-jun gene. The medical composition comprises a compound represented by the general formula (I) shown below: wherein R1, R2, and R3 represent —H, a linear or branched alkyl group with 1 to 3 carbon atoms, and R4 represents —H or a benzyl group.
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