公开(公告)号：US10745370B2

公开(公告)日：2020-08-18

申请号：US16087103

申请日：2017-03-20

Applicant: Yu-Jen Chen

Inventor： Yu-Jen Chen ,  Lie-Chwen Lin

IPC: C07D311/22 ,  A61P37/06 ,  A61P25/28 ,  A61P35/00

Abstract: Disclosed herein are novel compounds and uses thereof. The present compounds may suppress the activity of farnesyl transferase and thus, may act as modulators of immune cells; therefor, they are useful for the development of a medicament for treating diseases that are associated with or caused by excessive levels of farnesyl transferase or immune response. Also disclosed herein are pharmaceutical compositions containing the present compounds.

公开(公告)号：US09572545B2

公开(公告)日：2017-02-21

申请号：US13466142

申请日：2012-05-08

Applicant: Yu-Jen Chen ,  Chia-Yuan Liu ,  Wen-Chung Chang ,  Chin-Sheng Chen

Inventor： Yu-Jen Chen ,  Chia-Yuan Liu ,  Wen-Chung Chang ,  Chin-Sheng Chen

IPC: A61B8/08 ,  A61B8/00 ,  A61N5/10

CPC classification number: A61B8/085 ,  A61B8/4218 ,  A61B8/4263 ,  A61B8/523 ,  A61B8/5261 ,  A61B8/565 ,  A61B8/587 ,  A61N5/1037 ,  A61N5/1067 ,  A61N2005/1058 ,  G06T7/187 ,  G06T7/33 ,  G06T2207/10081 ,  G06T2207/10132 ,  G06T2207/20032 ,  G06T2207/20061 ,  G06T2207/30056

Abstract: The present invention provides a radiotherapy system that can monitor a target location in real time. The radiotherapy system includes a remote control system operable to actuate a real-time image capturing device to acquire images in real time for monitoring the target location. The system also includes an image registration system that can register the acquired image with an image previously captured for the treatment plan, whereby it can be determined whether the patient's tumor is in the beam's eye view of the treatment plan. By confirming that the tumor is in the range of the beam's eye view, the accuracy of the treatment can be improved, and the irradiated area can be reduced, which makes the radiation treatment safer.

Abstract translation: 本发明提供了可以实时监视目标位置的放射治疗系统。 放射治疗系统包括可操作以致动实时图像捕获装置以实时获取图像的遥控系统，用于监视目标位置。 该系统还包括一个图像配准系统，其可以用先前为治疗计划拍摄的图像来注册所获取的图像，从而可以确定患者的肿瘤是否处于治疗计划的眼睛视图中。 通过确认肿瘤在眼睛的视野范围内，可以提高治疗的准确性，并且可以减少照射面积，这使得放射治疗更安全。

公开(公告)号：US08846768B2

公开(公告)日：2014-09-30

申请号：US13595170

申请日：2012-08-27

Applicant: Yu-Jen Chen ,  Lie-Chwn Lin ,  Ching-Pin Lin

Inventor： Yu-Jen Chen ,  Lie-Chwn Lin ,  Ching-Pin Lin

IPC: A61K31/015 ,  A61K33/24 ,  A61K31/336 ,  A61K31/045

CPC classification number: A61K31/336 ,  A61K31/045 ,  A61K31/575 ,  A61K33/24 ,  A61K2300/00

Abstract: Novel Uses of small molecules, particularly, triterpenoids and ingol diterpenes isolated from Euphorbia neriifolia, are disclosed herein. The triterpenoids are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer; whereas the ingol diterpenes are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating thrombocytopenia.

Abstract translation: 本文公开了小分子特别是分离自大戟属的三萜类化合物和多糖二萜类的新型用途。 三萜类化合物可用作制备用于治疗癌症的药物或药物组合物的铅化合物; 而二醇二萜可用作制备用于治疗血小板减少症的药物或药物组合物的铅化合物。

公开(公告)号：US08691870B2

公开(公告)日：2014-04-08

申请号：US13243128

申请日：2011-09-23

Applicant: Yu-Jen Chen ,  Hui-Fen Liao

Inventor： Yu-Jen Chen ,  Hui-Fen Liao

IPC: A61K31/26 ,  C07C331/00

CPC classification number: A61K31/26

Abstract: Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly drug-resistant cancer, in a patient.

Abstract translation: 本文公开了小分子，特别是异硫氰酸6-甲基亚磺酰基己酯和异硫氰酸6-甲基磺酰基己酯的新用途。 两种异硫氰酸酯可用作制造用于治疗患者中的癌症，特别是耐药性癌症的药物或药物组合物的铅化合物。

公开(公告)号：US20140056995A1

公开(公告)日：2014-02-27

申请号：US13595170

申请日：2012-08-27

Applicant: YU-JEN CHEN ,  Lie-Chwn Lin ,  Ching-Pin Lin

Inventor： YU-JEN CHEN ,  Lie-Chwn Lin ,  Ching-Pin Lin

IPC: A61K31/336 ,  A61K33/24 ,  A61K31/045

CPC classification number: A61K31/336 ,  A61K31/045 ,  A61K31/575 ,  A61K33/24 ,  A61K2300/00

Abstract: Novel Uses of small molecules, particularly, triterpenoids and ingol diterpenes isolated from Euphorbia neriifolia, are disclosed herein. The triterpenoids are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer; whereas the ingol diterpenes are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating thrombocytopenia.

Abstract translation: 本文公开了小分子特别是分离自大戟属的三萜类化合物和多糖二萜类的新型用途。 三萜类化合物可用作制备用于治疗癌症的药物或药物组合物的铅化合物; 而二醇二萜可用作制备用于治疗血小板减少症的药物或药物组合物的铅化合物。

公开(公告)号：US08546366B2

公开(公告)日：2013-10-01

申请号：US13483620

申请日：2012-05-30

Applicant: Yu-Jen Chen ,  Cheng-Jen Chou ,  Tun-Tschu Chang

Inventor： Yu-Jen Chen ,  Cheng-Jen Chou ,  Tun-Tschu Chang

IPC: A61K31/56 ,  A61K38/00 ,  A61P35/00

CPC classification number: A61K31/575

Abstract: In this patent, we isolated a novel compound from fruiting body of Antrodia cinnamomea, namely, (22R)-5α-lanosta-8,24-dien-3β,15α,21-triol. This compound possesses preferential cytotoxicity against human leukemia, pancreatic cancer, esophageal cancer, hepatoma, and cervical cancer cells.

Abstract translation: 在这项专利中，我们从番茄子实体中分离出一种新的化合物，即（22R）-5α-羊毛甾-8,24-二烯-3β，15α，21-三醇。 该化合物对人白血病，胰腺癌，食管癌，肝癌和宫颈癌细胞具有优先的细胞毒性。

公开(公告)号：US20130141061A1

公开(公告)日：2013-06-06

申请号：US13655401

申请日：2012-10-18

Applicant: YU-JEN CHEN ,  CHUN-YUAN TIEN ,  FAN-CHIN KUNG ,  CHUN-PO CHEN ,  CHIA-MING YEH

Inventor： YU-JEN CHEN ,  CHUN-YUAN TIEN ,  FAN-CHIN KUNG ,  CHUN-PO CHEN ,  CHIA-MING YEH

IPC: G05F1/10

CPC classification number: H02M1/32 ,  H02M3/1588 ,  Y02B70/1466

Abstract: A buck converter configured for converting a voltage output from a power supply to a load includes a first switch, a second switch, an inductor, three compensators and a control microchip. The first switch and the second switch are connected in series between two ends of the power supply. A first end of the inductor is connected to a node between the first switch and the second switch; a second end of the inductor serves as an output terminal connected to the load. The compensators are correspondingly connected to the first switch, the second switch and the inductor. The control microchip is electrically connected to the first and second switches and the node. The control microchip controls the first and second switches to turn on or off, and executes a current protective process when output current of the output terminal exceeds a current protective threshold of the load.

Abstract translation: 被配置为将从电源输出的电压转换为负载的降压转换器包括第一开关，第二开关，电感器，三个补偿器和控制微芯片。 第一开关和第二开关串联在电源的两端之间。 电感器的第一端连接到第一开关和第二开关之间的节点; 电感器的第二端用作连接到负载的输出端子。 补偿器相应地连接到第一开关，第二开关和电感器。 控制微芯片电连接到第一和第二开关和节点。 控制微芯片控制第一和第二开关导通或关断，并且当输出端子的输出电流超过负载的当前保护阈值时执行当前的保护处理。

公开(公告)号：US08456433B2

公开(公告)日：2013-06-04

申请号：US12632931

申请日：2009-12-08

Applicant: Yu Jen Chen

Inventor： Yu Jen Chen

IPC: G06F3/041

CPC classification number: G06F3/04886 ,  G06F3/0488 ,  G06F2203/04808

Abstract: The present invention provides a signal processing apparatus and a signal processing method of a man-machine interface. The signal processing method comprises steps of: receiving a first touch signal; recognizing an object corresponding to the first touch signal; determining whether a second touch signal is received while receiving the first touch signal; and selecting the object corresponding to the first touch signal when receiving the second touch signal.

Abstract translation: 本发明提供一种人机接口的信号处理装置和信号处理方法。 信号处理方法包括以下步骤：接收第一触摸信号; 识别与第一触摸信号对应的对象; 确定在接收到所述第一触摸信号的同时是否接收到第二触摸信号; 以及当接收到第二触摸信号时选择与第一触摸信号对应的对象。

公开(公告)号：US20120309732A1

公开(公告)日：2012-12-06

申请号：US13483620

申请日：2012-05-30

Applicant: Yu-Jen Chen ,  Cheng-Jen Chou ,  Tun-Tschu Chang

Inventor： Yu-Jen Chen ,  Cheng-Jen Chou ,  Tun-Tschu Chang

IPC: A61K31/56 ,  A61P35/04 ,  A61P35/02 ,  C12N5/09

CPC classification number: A61K31/575

Abstract: In this patent, we isolated a novel compound from fruiting body of Antrodia cinnamomea, namely, (22R)-5α-lanosta-8,24-dien-3β,15α,21-triol. This compound possesses preferential cytotoxicity against human leukemia, pancreatic cancer, esophageal cancer, hepatoma, and cervical cancer cells.

Abstract translation: 在该专利中，我们分离出了一种新型的化合物，即，（22R）-5α-lanosta-8,24-二烯-3和bgr，15α，21-三醇的子实体。 该化合物对人白血病，胰腺癌，食管癌，肝癌和宫颈癌细胞具有优先的细胞毒性。

公开(公告)号：US08310215B2

公开(公告)日：2012-11-13

申请号：US12777437

申请日：2010-05-11

Applicant: Chen-Kun Chou ,  Zhan-Yi Lin ,  Ting-Kuan Li ,  Yu-Jen Chen ,  Chi-Bin Wu

Inventor： Chen-Kun Chou ,  Zhan-Yi Lin ,  Ting-Kuan Li ,  Yu-Jen Chen ,  Chi-Bin Wu

IPC: G05F1/70

CPC classification number: G05F1/575

Abstract: A linear modulation voltage transformer circuitry includes a power stage unit, a voltage division unit, a linear modulation unit, an error amplifier, and a recursive controller. The power stage unit adapts an input voltage and outputs a first voltage to the voltage division unit, which outputs a divided voltage. The linear modulation unit receives the divided voltage, compares it with a control voltage, and outputs an error voltage signal to the error amplifier, which amplifies the error voltage signal as an error gain control signal. The recursive controller receives and modulates the error gain control signal and outputs the modulation error gain control signal to the power stage unit as a reference signal so as for the power stage unit to modulate the first voltage. Thus, the first voltage can be varied in real time via the linear modulation unit to meet load demands.

Abstract translation: 线性调制电压互感器电路包括功率级单元，分压单元，线性调制单元，误差放大器和递归控制器。 功率级单元适应输入电压，并向分压单元输出第一电压，分压单元输出分压。 线性调制单元接收分压，将其与控制电压进行比较，并将误差电压信号输出到误差放大器，该误差放大器将误差电压信号放大为误差增益控制信号。 递归控制器接收并调制误差增益控制信号，并将调制误差增益控制信号输出到功率级单元作为参考信号，以使功率级单元调制第一电压。 因此，可以经由线性调制单元实时地改变第一电压以满足负载需求。