发明申请
- 专利标题： PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3
- 专利标题（中）： 吡咯基合成酶抑制剂3
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申请号： US11761937申请日： 2007-06-12
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公开(公告)号： US20070244109A1公开(公告)日： 2007-10-18
- 发明人: Manoj Desai , Simon Ng , Zhi-Jie Ni , Keith Pfister , Savithri Ramurthy , Sharadha Subramanian , Allan Wagman
- 申请人： Manoj Desai , Simon Ng , Zhi-Jie Ni , Keith Pfister , Savithri Ramurthy , Sharadha Subramanian , Allan Wagman
- 申请人地址： US CA Emeryville
- 专利权人： NOVARTIS VACCINES AND DIAGNOSTICS, INC.
- 当前专利权人： NOVARTIS VACCINES AND DIAGNOSTICS, INC.
- 当前专利权人地址： US CA Emeryville
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/445 ; A61K31/497 ; A61K31/535 ; A61P25/28 ; A61P3/10
摘要：
New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
公开/授权文献
- US07671049B2 Pyrrole based inhibitors of glycogen synthase kinase 3 公开/授权日：2010-03-02
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