发明申请
- 专利标题: Piperazinediones as Oxytocin Receptor Antagonists
- 专利标题(中): 哌嗪类作为催产素受体拮抗剂
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申请号: US11630179申请日: 2005-06-21
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公开(公告)号: US20070254888A1公开(公告)日: 2007-11-01
- 发明人: Alan Borthwick , Deirdre Mary Hickey , John Liddle , Andrew Mason
- 申请人: Alan Borthwick , Deirdre Mary Hickey , John Liddle , Andrew Mason
- 申请人地址: GB Greenford Middlesex UB6 0NN
- 专利权人: GLAXO GROUP LIMITED
- 当前专利权人: GLAXO GROUP LIMITED
- 当前专利权人地址: GB Greenford Middlesex UB6 0NN
- 优先权: GB0414093.5 20040623
- 国际申请: PCT/EP05/06760 WO 20050621
- 主分类号: A61K31/495
- IPC分类号: A61K31/495 ; A61P15/06 ; C07D241/02
摘要:
Compounds of formula (I) wherein R1 is 2-indanyl, R2 is 1-methylpropyl, R3 is a group selected from 2,6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R4 represents methyl and R5 represents hydrogen or methyl or, R4 and R5 together with the nitrogen atom to which they are attached represent morpholino and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists.
公开/授权文献
- US07550462B2 Piperazinediones as oxytocin receptor antagonists 公开/授权日:2009-06-23
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