利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

11 条记录 (耗时 0.021 秒)

    Substituted Diketopiperazines as Oxytocin Antagonists
    2.
    发明申请
    Substituted Diketopiperazines as Oxytocin Antagonists 审中-公开
    取代的二酮哌嗪作为催产素拮抗剂

    公开(公告)号：US20070208031A1

    公开(公告)日：2007-09-06

    申请号：US11630097

    申请日：2005-06-21

    申请人： Alan Borthwick ,  Steven Sollis

    发明人： Alan Borthwick ,  Steven Sollis

    IPC分类号： A61K31/496 ,  C07D403/02

    CPC分类号： C07D403/06

    摘要： Compounds of formula (IA) wherein R1 is 2-indanyl, R2 is 1-methylpropyl, R3 is 1-methyl-indazol-5-yl, R4 represents methyl and R5 represents hydrogen or methyl, and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists.

    摘要翻译： 其中R 1是2-二氢茚基，R 2的式（IA）化合物是1-甲基丙基，R 3是1-甲基 - 吲唑 -5-基，R 4代表甲基，R 5表示氢或甲基，并且其药学上可接受的衍生物被描述，其制备方法，含有它们的药物组合物 及其在医药中的用途，特别是用作催产素拮抗剂。

    Piperazinediones as Oxytocin Receptor Antagonists
    4.
    发明申请
    Piperazinediones as Oxytocin Receptor Antagonists 有权
    哌嗪类作为催产素受体拮抗剂

    公开(公告)号：US20070254888A1

    公开(公告)日：2007-11-01

    申请号：US11630179

    申请日：2005-06-21

    申请人： Alan Borthwick ,  Deirdre Mary Hickey ,  John Liddle ,  Andrew Mason

    发明人： Alan Borthwick ,  Deirdre Mary Hickey ,  John Liddle ,  Andrew Mason

    IPC分类号： A61K31/495 ,  A61P15/06 ,  C07D241/02

    CPC分类号： A61K31/5377 ,  C07D401/06 ,  C07D413/14

    摘要： Compounds of formula (I) wherein R1 is 2-indanyl, R2 is 1-methylpropyl, R3 is a group selected from 2,6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R4 represents methyl and R5 represents hydrogen or methyl or, R4 and R5 together with the nitrogen atom to which they are attached represent morpholino and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists.

    摘要翻译： 其中R 1为2-二氢茚基，R 2的式（I）化合物为1-甲基丙基，R 3为选自2 ，6-二甲基-3-吡啶基或4,6-二甲基-3-吡啶基，R 4表示甲基，R 5表示氢或甲基，或者R 1， 4和R 5与它们所连接的氮原子一起代表吗啉代及其药学上可接受的衍生物，其制备方法，含有它们的药物组合物及其用途 药物，特别是它们作为催产素拮抗剂的用途。