Invention Application
US20070254920A1 Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
审中-公开
使用具有同位羟基的醇的酸的前药衍生物及其制备和使用方法
- Patent Title: Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
- Patent Title (中): 使用具有同位羟基的醇的酸的前药衍生物及其制备和使用方法
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Application No.: US11412207Application Date: 2006-04-26
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Publication No.: US20070254920A1Publication Date: 2007-11-01
- Inventor: Mitchell deLong , Jill McFadden , Susan Royalty , Eric Toone , Jeffrey Yingling
- Applicant: Mitchell deLong , Jill McFadden , Susan Royalty , Eric Toone , Jeffrey Yingling
- Applicant Address: US NC Research Triangle Park
- Assignee: Aerie Pharmaceuticals, Inc.
- Current Assignee: Aerie Pharmaceuticals, Inc.
- Current Assignee Address: US NC Research Triangle Park
- Main IPC: A61K31/558
- IPC: A61K31/558 ; C07D409/02 ; C07D405/02 ; C07D403/02
Abstract:
This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula wherein is a biologically-active moiety comprising a carboxylic acid functional group, and Rb is a homotopically-symmetrical alcohol bonded to the biologically-active moiety through the carboxylic acid functional group to form an ester linkage, as well as optical isomers, enantiomers, pharmaceutically acceptable salts, biohydrolyzable amides, esters, and imides thereof and combinations thereof.
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