公开(公告)号：US20060121069A1

公开(公告)日：2006-06-08

申请号：US11334689

申请日：2006-01-18

Applicant: Mitchell DeLong ,  John McIver ,  Robert Youngquist

Inventor： Mitchell DeLong ,  John McIver ,  Robert Youngquist

IPC: A61K38/13 ,  A61K31/557 ,  A61K31/41

CPC classification number: A61Q7/00 ,  A61K8/14 ,  A61K8/40 ,  A61K8/41 ,  A61K8/44 ,  A61K8/447 ,  A61K8/46 ,  A61K31/5575 ,  A61Q1/10 ,  A61Q5/02

Abstract: A method for treating hair loss in mammals uses compositions containing prostaglandins analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.

公开(公告)号：US20050124587A1

公开(公告)日：2005-06-09

申请号：US11035602

申请日：2005-01-14

Applicant: Mitchell DeLong

Inventor： Mitchell DeLong

IPC: C07C405/00 ,  C07F9/30 ,  C07F9/6533 ,  C07F9/6539 ,  C07F9/655 ,  C07F9/6553 ,  A61K31/665 ,  A61K31/66 ,  C07F9/28

CPC classification number: C07F9/303 ,  C07C405/0008 ,  C07F9/6533 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/65517 ,  C07F9/655354

Abstract: 2-Decarboxy-2-phosphinico prostaglandin derivatives are disclosed. These derivatives comprise a modified a-chain and an Ω-chain bonded to a ring structure. The modified α-chain has a 2-decarboxy-2-phosphinico group. The derivatives can be used to treat a variety of pharmaceutical and cosmetic conditions.

Abstract translation: 2-Decarboxy-2-phosphinico前列腺素衍生物被公开。 这些衍生物包含与环结构键合的改性的a链和ω-链。 改性的α-链具有2-脱羧基-2-亚磷酸基团。 衍生物可用于治疗各种药物和美容条件。

公开(公告)号：US20080103184A1

公开(公告)日：2008-05-01

申请号：US11967423

申请日：2007-12-31

Applicant: Mitchell DeLong ,  John McIver ,  Robert Youngquist

Inventor： Mitchell DeLong ,  John McIver ,  Robert Youngquist

IPC: A61K31/426 ,  A61K31/19 ,  A61P43/00 ,  A61K31/381

CPC classification number: A61K8/49 ,  A61K8/365 ,  A61K8/37 ,  A61K8/4986 ,  A61K31/19 ,  A61K31/192 ,  A61K31/381 ,  A61K31/428 ,  A61K31/5575 ,  A61K31/559 ,  A61K45/06 ,  A61Q7/00

Abstract: A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.

Abstract translation: 用于治疗哺乳动物脱发的方法使用含有前列腺素F类似物的组合物。 组合物可以局部施用于皮肤。 组合物可以阻止脱发，逆转脱发，并促进毛发生长。

公开(公告)号：US20070254920A1

公开(公告)日：2007-11-01

申请号：US11412207

申请日：2006-04-26

Applicant: Mitchell deLong ,  Jill McFadden ,  Susan Royalty ,  Eric Toone ,  Jeffrey Yingling

Inventor： Mitchell deLong ,  Jill McFadden ,  Susan Royalty ,  Eric Toone ,  Jeffrey Yingling

IPC: A61K31/558 ,  C07D409/02 ,  C07D405/02 ,  C07D403/02

CPC classification number: C07C219/10 ,  C07C69/608 ,  C07C69/738 ,  C07C69/76 ,  C07C233/65 ,  C07C251/48 ,  C07C317/44 ,  C07C405/00 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/24 ,  C07D205/095 ,  C07D215/56 ,  C07D233/78 ,  C07D277/06 ,  C07D295/116 ,  C07D333/56 ,  C07D333/64 ,  C07D473/30 ,  C07D473/34 ,  C07D491/056 ,  C07D501/34

Abstract: This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula wherein is a biologically-active moiety comprising a carboxylic acid functional group, and Rb is a homotopically-symmetrical alcohol bonded to the biologically-active moiety through the carboxylic acid functional group to form an ester linkage, as well as optical isomers, enantiomers, pharmaceutically acceptable salts, biohydrolyzable amides, esters, and imides thereof and combinations thereof.

Abstract translation: 本发明涉及新的同位素前药和药物及其制备，测试和使用的方法。 在一个实施方案中，同位物前药具有以下通式：其中是包含羧酸官能团的生物活性部分，并且R bb是与生物活性部分结合的同位素对称醇，通过 羧酸官能团以形成酯键，以及光学异构体，对映异构体，药学上可接受的盐，生物可水解的酰胺，酯和酰亚胺以及它们的组合。

公开(公告)号：US20070173530A1

公开(公告)日：2007-07-26

申请号：US11621892

申请日：2007-01-10

Applicant: Mitchell deLong ,  Jill Sturdivant ,  Geoffrey Heintzelman ,  Susan Royalty

Inventor： Mitchell deLong ,  Jill Sturdivant ,  Geoffrey Heintzelman ,  Susan Royalty

IPC: A61K31/4709 ,  C07D409/02 ,  C07D217/02

CPC classification number: C07D217/02

Abstract: 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.

Abstract translation: 提供了影响，抑制或减少激酶作用的6-氨基异喹啉化合物。 还提供包含治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状况或病症如癌症，肥胖症和青光眼的各种方法。

公开(公告)号：US20070092466A1

公开(公告)日：2007-04-26

申请号：US11565297

申请日：2006-11-30

Applicant: Mitchell deLong ,  John McIver ,  Robert Youngquist

Inventor： Mitchell deLong ,  John McIver ,  Robert Youngquist

IPC: A61K8/49 ,  A61K8/36 ,  A61K8/37 ,  A61K38/13 ,  A61K31/557

CPC classification number: A61Q7/00 ,  A61K8/365 ,  A61K8/46 ,  A61K31/5575

Abstract: A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.

Abstract translation: 用于治疗哺乳动物脱发的方法使用含有前列腺素F类似物的组合物。 组合物可以局部施用于皮肤。 组合物可以阻止脱发，逆转脱发，并促进毛发生长。

公开(公告)号：US20060135609A1

公开(公告)日：2006-06-22

申请号：US11255478

申请日：2005-10-21

Applicant: Eric Toone ,  David Epstein ,  Pratap Challa ,  Phillip Snyder ,  Xin Chen ,  Mitchell deLong

Inventor： Eric Toone ,  David Epstein ,  Pratap Challa ,  Phillip Snyder ,  Xin Chen ,  Mitchell deLong

IPC: A61K31/225

CPC classification number: A61K31/225 ,  A61K31/712 ,  C07C69/712 ,  C07C69/738 ,  C07H13/04

Abstract: The present invention relates generally to ophthamological drugs. More specifically, the inventon relates to a method of modifying (derivatizing) ophthamological drugs so as to increase their penetration through the cornea. The invention also relates to drugs modified (derivatized) in accordance with the instant method and to the use of same in treating conditions associated with elevated intraocular pressure, particularly, glaucoma.

Abstract translation: 本发明一般涉及眼科药物。 更具体地，本发明涉及一种改变（衍生化）眼科药物以增加其穿透角膜的方法。 本发明还涉及根据本发明方法修饰（衍生化）的药物，以及在治疗与眼内压升高相关的病症，特别是青光眼中的用途。

公开(公告)号：US20050124588A1

公开(公告)日：2005-06-09

申请号：US11035603

申请日：2005-01-14

Applicant: Mitchell DeLong

Inventor： Mitchell DeLong

IPC: C07C405/00 ,  C07F9/30 ,  C07F9/6533 ,  C07F9/6539 ,  C07F9/655 ,  C07F9/6553 ,  A61K31/665 ,  A61K31/66

CPC classification number: C07F9/303 ,  C07C405/0008 ,  C07F9/6533 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/65517 ,  C07F9/655354

Abstract: 2-Decarboxy-2-phosphinico prostaglandin derivatives are disclosed. These derivatives comprise a modified a-chain and an Q-chain bonded to a ring structure. The modified a-chain has a 2-decarboxy-2-phosphinico group. The derivatives can be used to treat a variety of pharmaceutical and cosmetic conditions.

Abstract translation: 2-Decarboxy-2-phosphinico前列腺素衍生物被公开。 这些衍生物包含与环结构键合的改性α-链和Q链。 改性的a链具有2-脱羧基-2-亚磷酸基团。 衍生物可用于治疗各种药物和美容条件。

公开(公告)号：US20070142429A1

公开(公告)日：2007-06-21

申请号：US11485172

申请日：2006-07-11

Applicant: Mitchell deLong ,  Marcos Sznaidman ,  Robert Oakley ,  Allen Eckhardt ,  Christine Hudson ,  Jeffrey Yingling ,  Michael Peel ,  Thomas Richardson ,  Clare Murray ,  Byappanahally Rao ,  Brian Heasley ,  Paresma Patel

Inventor： Mitchell deLong ,  Marcos Sznaidman ,  Robert Oakley ,  Allen Eckhardt ,  Christine Hudson ,  Jeffrey Yingling ,  Michael Peel ,  Thomas Richardson ,  Clare Murray ,  Byappanahally Rao ,  Brian Heasley ,  Paresma Patel

IPC: A61K31/47

CPC classification number: C07D217/02

Abstract: Isoquinoline compounds with G are provided that influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of the isoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, osteoporosis and glaucoma are also provided.

Abstract translation: 提供了具有G的异喹啉化合物，其影响，抑制或降低G蛋白受体激酶的作用。 还提供包含治疗有效量的异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状态或病症如癌症，骨质疏松症和青光眼的各种方法。

公开(公告)号：US20070135499A1

公开(公告)日：2007-06-14

申请号：US11485182

申请日：2006-07-11

Applicant: Mitchell deLong ,  Marcos Sznaidman ,  Robert Oakley ,  Allen Eckhardt ,  Christine Hudson ,  Jeffrey Yingling ,  Michael Peel ,  Thomas Richardson ,  Clare Murray ,  Byappanahally Narasinga Rao ,  Brian Heasley ,  Paresma Patel

Inventor： Mitchell deLong ,  Marcos Sznaidman ,  Robert Oakley ,  Allen Eckhardt ,  Christine Hudson ,  Jeffrey Yingling ,  Michael Peel ,  Thomas Richardson ,  Clare Murray ,  Byappanahally Narasinga Rao ,  Brian Heasley ,  Paresma Patel

IPC: A61K31/44

CPC classification number: C07D401/12 ,  C07D213/53 ,  C07D213/61 ,  C07D213/75 ,  C07D215/12 ,  C07D215/42 ,  C07D233/64 ,  C07D239/52 ,  C07D239/54 ,  C07D307/14 ,  C07D307/52 ,  C07D333/22 ,  C07D401/14

Abstract: Hydrazide compounds with GPCR desensitization inhibitory activity are provided that may be used to influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of the hydrazide compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions controlled or influenced by GPCRs are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, osteoporosis and glaucoma are also provided.

Abstract translation: 提供具有GPCR脱敏抑制活性的酰肼化合物，其可用于影响，抑制或降低G蛋白受体激酶的作用。 还提供包含治疗有效量的酰肼化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响受GPCR控制或影响的疾病状态或病症的各种方法。 还提供了使用化合物和/或组合物影响疾病状态或病症如癌症，骨质疏松症和青光眼的各种方法。