发明申请
- 专利标题: Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
- 专利标题(中): 含有氟和三氟烷基的杂环磺酰胺抑制剂β淀粉样蛋白产生及其衍生物
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申请号: US11818630申请日: 2007-06-15
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公开(公告)号: US20070254929A1公开(公告)日: 2007-11-01
- 发明人: Anthony Kreft , Lynn Resnick , Scott Mayer , George Diamantidis , Derek Cole , Boyd Harrison , Minsheng Zhang , Molly Hoke , Tingzhong Wang , Rocco Galante
- 申请人: Anthony Kreft , Lynn Resnick , Scott Mayer , George Diamantidis , Derek Cole , Boyd Harrison , Minsheng Zhang , Molly Hoke , Tingzhong Wang , Rocco Galante
- 申请人地址: US NJ Madison 07940
- 专利权人: Wyeth
- 当前专利权人: Wyeth
- 当前专利权人地址: US NJ Madison 07940
- 主分类号: A61K31/433
- IPC分类号: A61K31/433 ; A61P25/00 ; C07D285/08
摘要:
Compounds of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)nalkyl, (CF3)n(substitutedalkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substitutedphenyl), or (F)ncycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y═C, or substituted diene fused to Y when Y═C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.