发明申请
US20070258973A1 Diagnostics and Therapeutics for Diseases Associated with Tripeptidyl-Peptidase 2(Tpp2)
审中-公开
与三肽基肽酶2（Tpp2）相关的疾病的诊断和治疗
- 专利标题： Diagnostics and Therapeutics for Diseases Associated with Tripeptidyl-Peptidase 2(Tpp2)
- 专利标题（中）： 与三肽基肽酶2（Tpp2）相关的疾病的诊断和治疗
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申请号： US10586492申请日： 2005-01-19
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公开(公告)号： US20070258973A1公开(公告)日： 2007-11-08
- 发明人: Stefan Golz , Ulf Bruggemeier , Andreas Geerts , Holger Summer
- 申请人： Stefan Golz , Ulf Bruggemeier , Andreas Geerts , Holger Summer
- 申请人地址： DE Leverkusen 51368
- 专利权人： BAYER HEALTHCARE AG
- 当前专利权人： BAYER HEALTHCARE AG
- 当前专利权人地址： DE Leverkusen 51368
- 优先权： EP04002139.6 20040131
- 国际申请： PCT/EP05/00472 WO 20050119
- 主分类号： A61K31/7105
- IPC分类号： A61K31/7105 ; A61K38/02 ; A61K38/43 ; A61K39/395 ; A61P43/00 ; C12Q1/68 ; G01N33/53
摘要：
The invention provides a human TPP2 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of TPP2 as well as pharmaceutical compositions comprising such compounds.
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