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26 条记录 (耗时 0.035 秒)

    Diagnostics and Therapeutics for Diseases Associated with Putative Cysteine Protease 1 (Prs1)
    1.
    发明申请
    Diagnostics and Therapeutics for Diseases Associated with Putative Cysteine Protease 1 (Prs1) 审中-公开
    与推定半胱氨酸蛋白酶1（Prs1）相关的疾病诊断与治疗

    公开(公告)号：US20070269807A1

    公开(公告)日：2007-11-22

    申请号：US10588207

    申请日：2005-01-22

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer ,  Ralf Thiele

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer ,  Ralf Thiele

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/37 ,  C12N9/641 ,  G01N2500/10

    摘要： The invention provides a human PRSC1 which is associated with the cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSC1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，癌症，内分泌疾病，代谢疾病，炎症，胃肠病，血液疾病，呼吸系统疾病，神经系统疾病和泌尿系疾病相关的人PRSC1。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，内分泌疾病，代谢疾病，炎症，胃肠疾病，血液疾病，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制PRSC1的活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and Therapeutics for Diseases Associated with Tripeptidyl-Peptidase 2(Tpp2)
    2.
    发明申请
    Diagnostics and Therapeutics for Diseases Associated with Tripeptidyl-Peptidase 2(Tpp2) 审中-公开
    与三肽基肽酶2（Tpp2）相关的疾病的诊断和治疗

    公开(公告)号：US20070258973A1

    公开(公告)日：2007-11-08

    申请号：US10586492

    申请日：2005-01-19

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    IPC分类号： A61K31/7105 ,  A61K38/02 ,  A61K38/43 ,  A61K39/395 ,  A61P43/00 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/57449 ,  C12Q1/37 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57442 ,  G01N33/57446 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2500/00

    摘要： The invention provides a human TPP2 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of TPP2 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，胃肠疾病，癌症，炎症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人类TPP2。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，胃肠疾病，癌症，炎症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病的化合物的化合物和 泌尿系疾病 本发明还涉及结合和/或活化或抑制TPP2活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 85 (gpr85)
    3.
    发明申请
    Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 85 (gpr85) 审中-公开
    与g蛋白偶联受体85（gpr85）相关疾病的诊断和治疗

    公开(公告)号：US20070071753A1

    公开(公告)日：2007-03-29

    申请号：US10576792

    申请日：2004-10-19

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    IPC分类号： A61K48/00 ,  A61K38/55 ,  G01N33/567 ,  G01N33/574 ,  A61K39/395

    CPC分类号： G01N33/566 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/6896 ,  G01N2021/6439 ,  G01N2333/726

    摘要： The invention provides a human GPR85 which is associated with the cardiovascular disorders, hematological disorders, inflammatory diseases, metabolic diseases, neurological disorders, urological disorders, respiratory diseases, cancer disorders and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, hematological disorders, inflammatory diseases, metabolic diseases, neurological disorders, urological disorders, respiratory diseases, cancer disorders and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR85 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，血液病，炎性疾病，代谢疾病，神经障碍，泌尿系统疾病，呼吸系统疾病，癌症病症和繁殖障碍有关的人GPR85。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液病症，炎性疾病，代谢疾病，神经障碍，泌尿系统疾病，呼吸系统疾病，癌症病症和繁殖障碍的化合物的测定。 本发明还涉及结合和/或活化或抑制GPR85活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and Therapeutics for Diseases Associated with Plasma Kallikrein (KLKB1)
    4.
    发明申请
    Diagnostics and Therapeutics for Diseases Associated with Plasma Kallikrein (KLKB1) 审中-公开
    血浆激肽释放酶（KLKB1）相关疾病诊断与治疗

    公开(公告)号：US20070253949A1

    公开(公告)日：2007-11-01

    申请号：US10588234

    申请日：2005-01-22

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K39/395 ,  G01N33/53

    CPC分类号： C12Q1/37 ,  G01N33/573 ,  G01N33/6893

    摘要： The invention provides a human KLKB1 which is associated with the cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, inflammatory diseases, cancer disorders, muscle-skeleton disorders, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, inflammatory diseases, cancer disorders, muscle-skeleton disorders, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLKB1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，内分泌系统和激素失调，代谢疾病，胃肠和肝脏疾病，炎性疾病，癌症，肌肉骨骼疾病，神经障碍和泌尿系统疾病相关的人KLKB1。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌系统和激素障碍，代谢疾病，胃肠和肝脏疾病，炎性疾病，癌症，肌肉骨骼疾病，神经障碍和泌尿系统疾病的化合物的测定 。 本发明还涉及结合和/或活化或抑制KLKB1活性的化合物以及包含这些化合物的药物组合物。

    CRTAC AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET
    5.
    发明申请
    CRTAC AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
    CRTAC作为生物标志物，治疗和诊断目标

    公开(公告)号：US20100081136A1

    公开(公告)日：2010-04-01

    申请号：US12444227

    申请日：2007-10-02

    申请人： Stefan Golz ,  Holger Summer ,  Andreas Geerts ,  Ulf Bruggemeier ,  Barbara Albrecht-Kupper ,  Martina Klein

    发明人： Stefan Golz ,  Holger Summer ,  Andreas Geerts ,  Ulf Bruggemeier ,  Barbara Albrecht-Kupper ,  Martina Klein

    IPC分类号： G01N33/53 ,  C12Q1/68

    CPC分类号： G01N33/6887 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： The invention provides CRTAC, which is associated with cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CRTAC as well as pharmaceutical compositions comprising such compounds. The invention also provides CRTAC as a biomarker for diseases such as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases.

    摘要翻译： 本发明提供了与心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病有关的CRTAC。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制CRTAC的活性的化合物以及包含这些化合物的药物组合物。 本发明还提供CRTAC作为心血管疾病，血液疾病，神经系统疾病，癌症，内分泌疾病和泌尿系疾病等疾病的生物标志物。

    Diagnostics and Therapeutics for Diseases Associated with Plasma Glutamate Carboxypeptidase (Pgcp)
    8.
    发明申请
    Diagnostics and Therapeutics for Diseases Associated with Plasma Glutamate Carboxypeptidase (Pgcp) 审中-公开
    与血浆谷氨酸羧肽酶（Pgcp）相关的疾病诊断和治疗

    公开(公告)号：US20070269421A1

    公开(公告)日：2007-11-22

    申请号：US10588067

    申请日：2005-01-22

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    IPC分类号： A61K31/7088 ,  A61K38/16 ,  A61K39/395 ,  A61P29/00 ,  A61P3/00 ,  A61P35/00 ,  A61P9/00 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/6896 ,  C12Q1/37 ,  G01N33/573 ,  G01N33/6893

    摘要： The invention provides a human PGCP which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urologial diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urologial diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PGCP as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人类PGCP。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经疾病和泌尿系疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制PGCP活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with kallikrein 12 (klk12)
    9.
    发明申请
    Diagnostics and therapeutics for diseases associated with kallikrein 12 (klk12) 审中-公开
    与激肽释放酶12相关的疾病的诊断和治疗（klk12）

    公开(公告)号：US20070148175A1

    公开(公告)日：2007-06-28

    申请号：US10586529

    申请日：2005-01-15

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/395 ,  A61K38/55

    CPC分类号： C12N9/6445

    摘要： The invention provides a human KLK12 which is associated with the gastrointestinal and liver diseases, cancer disorders, hematological diseases, inflammatory diseases, respiratory diseases, neurological disorders, cardiovascular disorders, reproduction disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of gastrointestinal and liver diseases, cancer disorders, hematological diseases, inflammatory diseases, respiratory diseases, neurological disorders, cardiovascular disorders, reproduction disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK12 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与胃肠和肝脏疾病，癌症疾病，血液疾病，炎性疾病，呼吸系统疾病，神经障碍，心血管疾病，繁殖障碍和泌尿系统疾病相关的人类KLK12。 本发明还提供了用于鉴定可用于治疗或预防胃肠和肝脏疾病，癌症疾病，血液疾病，炎性疾病，呼吸系统疾病，神经障碍，心血管疾病，繁殖障碍和泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制KLK12活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with dopamine receptor d4 (drd4)
    10.
    发明申请
    Diagnostics and therapeutics for diseases associated with dopamine receptor d4 (drd4) 审中-公开
    与多巴胺受体d4（drd4）相关疾病的诊断和治疗

    公开(公告)号：US20060263359A1

    公开(公告)日：2006-11-23

    申请号：US10548425

    申请日：2004-03-06

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Holger Summer

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Holger Summer

    IPC分类号： A61K48/00 ,  A61K38/54 ,  G01N33/53 ,  A61K39/395

    CPC分类号： G01N33/9413 ,  A61K48/00 ,  G01N2500/02 ,  G01N2500/04 ,  G01N2500/10

    摘要： The invention provides a human DRD4 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DRD4 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，胃肠和肝脏疾病，血液病症，神经障碍和呼吸系统疾病有关的人类DRD4。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠和肝脏疾病，血液病症，神经障碍和呼吸系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制DRD4的活性的化合物以及包含这些化合物的药物组合物。