发明申请
- 专利标题: Compositions and methods for treating cancer
- 专利标题(中): 用于治疗癌症的组合物和方法
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申请号: US10556220申请日: 2004-05-07
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公开(公告)号: US20070259956A1公开(公告)日: 2007-11-08
- 发明人: Craig Thompson , Daniel Bauer , Georgia Hatzivassiliou
- 申请人: Craig Thompson , Daniel Bauer , Georgia Hatzivassiliou
- 国际申请: PCT/US04/14263 WO 20040507
- 主分类号: A61K31/215
- IPC分类号: A61K31/215 ; A61K31/21
摘要:
Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
公开/授权文献
- US09060993B2 Compositions and methods for treating cancer 公开/授权日:2015-06-23
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