公开(公告)号：US20070259956A1

公开(公告)日：2007-11-08

申请号：US10556220

申请日：2004-05-07

申请人： Craig Thompson ,  Daniel Bauer ,  Georgia Hatzivassiliou

发明人： Craig Thompson ,  Daniel Bauer ,  Georgia Hatzivassiliou

IPC分类号： A61K31/215 ,  A61K31/21

CPC分类号： A61K31/34 ,  A61K51/0491

摘要： Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.

摘要翻译： 公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂治疗被鉴定为具有癌症的个体的方法。 公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂诱导癌细胞凋亡的方法。 公开了治疗患有癌症的个体的方法，包括将癌症鉴定为具有高比例的有氧糖酵解的步骤，以及施用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂。 公开了使用抑制ATP柠檬酸裂合酶或三羧酸转运蛋白的表达的化合物治疗患有癌症的个体的方法。 公开了鉴定具有抗癌活性的化合物的方法。

公开(公告)号：US09060993B2

公开(公告)日：2015-06-23

申请号：US10556220

申请日：2004-05-07

申请人： Craig B. Thompson ,  Daniel Bauer ,  Georgia Hatzivassiliou

发明人： Craig B. Thompson ,  Daniel Bauer ,  Georgia Hatzivassiliou

IPC分类号： A61K31/34 ,  A61K51/04

CPC分类号： A61K31/34 ,  A61K51/0491

摘要： Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tri-carboxylate transporter inhibitor are disclosed. of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.

摘要翻译： 公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂治疗被鉴定为具有癌症的个体的方法。 公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸酯转运蛋白抑制剂诱导癌细胞凋亡的方法。 公开了治疗患有癌症的个体的步骤，所述方法包括以下步骤：将癌症识别为具有高比例的需氧糖酵解，以及施用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂。 公开了使用抑制ATP柠檬酸裂合酶或三羧酸转运蛋白的表达的化合物治疗患有癌症的个体的方法。 公开了鉴定具有抗癌活性的化合物的方法。

公开(公告)号：US20120214828A1

公开(公告)日：2012-08-23

申请号：US13392405

申请日：2010-08-24

申请人： Georgia Hatzivassiliou ,  Shiva Malek

发明人： Georgia Hatzivassiliou ,  Shiva Malek

IPC分类号： A61K31/517 ,  G01N33/574 ,  A61P35/00 ,  C12Q1/68

CPC分类号： A61K31/517 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/156 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/5743 ,  G01N33/57438 ,  G01N33/57449 ,  G01N33/57492 ,  G01N33/57496 ,  G01N2333/91205 ,  G01N2333/914 ,  G01N2800/52

摘要： The present invention relates to prognostic methods for identifying tumors that are not susceptible to B-Raf inhibitor treatment by detecting mutations in a K-ras gene or protein or by detecting overexpression of RTKs and/or their ligands. Kits are also disclosed for carrying out the methods.

摘要翻译： 本发明涉及通过检测K-ras基因或蛋白质中的突变或通过检测RTK和/或其配体的过表达鉴定对B-Raf抑制剂治疗不敏感的肿瘤的预后方法。 还披露了用于实施这些方法的试剂盒。