Embodiments of the present invention address deficiencies of the art in respect to load balancing in an enterprise environment and provide a method, system and computer program product for garbage collection sensitive load balancing. In a first embodiment of the invention, a load balancing method can include selectively avoiding server resources experiencing garbage collection when routing workloads to server resources in a load balanced cluster of server resources. For example, selectively avoiding server resources experiencing garbage collection when routing workloads to server resources in a load balanced cluster of server resources, can include detecting a garbage collection operation in a particular server resource, and avoiding routing of a workload to the particular server resource until the garbage collection operation has completed.