发明申请
US20070269408A1 GENES OF IL-12p40 SUBUNIT MUTATED FOR IMPROVING THE ACTIVITY OF IL-12 AND USE THEREOF FOR DNA VACCINE ADJUVANT
有权
用于改善IL-12活性的IL-12p40亚基基因及其用于DNA疫苗补充剂的用途
- 专利标题： GENES OF IL-12p40 SUBUNIT MUTATED FOR IMPROVING THE ACTIVITY OF IL-12 AND USE THEREOF FOR DNA VACCINE ADJUVANT
- 专利标题（中）： 用于改善IL-12活性的IL-12p40亚基基因及其用于DNA疫苗补充剂的用途
-
申请号： US11832993申请日： 2007-08-02
-
公开(公告)号： US20070269408A1公开(公告)日： 2007-11-22
- 发明人: Young Chul SUNG , Sung Lee , Sang Ha , Man Song , Jun Chang
- 申请人： Young Chul SUNG , Sung Lee , Sang Ha , Man Song , Jun Chang
- 优先权： KR2000-13133 20000315; KR2001-12987 20010313
- 主分类号： A61K38/20
- IPC分类号： A61K38/20 ; A61K48/00 ; C07K14/54 ; C07H21/04 ; C12P21/04
摘要：
The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12 (interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it relates to IL-12p40 mutant gene which inhibits the secretion of IL-12p40 but normally secretes active IL-12p70 by making mutation at Asn-222 (human) or Asn-220 (mouse) amino acid of IL-12p40, which acts as a competitive inhibitor of active form of IL-12, IL-12p70. Therefore, the IL-12p40 mutant gene of the present invention can be useful for DNA vaccination and gene therapy against various diseases, for example, AIDS, hepatitis C or hepatitis B, cancer, influenza, tuberculosis and malaria, which essentially require cellular immune responses for their therapy.
公开/授权文献
信息查询
IPC分类:
