发明申请
US20070269421A1 Diagnostics and Therapeutics for Diseases Associated with Plasma Glutamate Carboxypeptidase (Pgcp)
审中-公开
与血浆谷氨酸羧肽酶（Pgcp）相关的疾病诊断和治疗
- 专利标题： Diagnostics and Therapeutics for Diseases Associated with Plasma Glutamate Carboxypeptidase (Pgcp)
- 专利标题（中）： 与血浆谷氨酸羧肽酶（Pgcp）相关的疾病诊断和治疗
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申请号： US10588067申请日： 2005-01-22
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公开(公告)号： US20070269421A1公开(公告)日： 2007-11-22
- 发明人: Stefan Golz , Ulf Bruggemeier , Andreas Geerts , Holger Summer
- 申请人： Stefan Golz , Ulf Bruggemeier , Andreas Geerts , Holger Summer
- 申请人地址： DE Leverkusen D-51368
- 专利权人： BAYER HEALTHCARE AG
- 当前专利权人： BAYER HEALTHCARE AG
- 当前专利权人地址： DE Leverkusen D-51368
- 优先权： EP04002288.1 20040203
- 国际申请： PCT/EP05/00611 WO 20050122
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; A61K38/16 ; A61K39/395 ; A61P29/00 ; A61P3/00 ; A61P35/00 ; A61P9/00 ; C12Q1/68 ; G01N33/53
摘要：
The invention provides a human PGCP which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urologial diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urologial diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PGCP as well as pharmaceutical compositions comprising such compounds.