发明申请
US20070269487A1 Drug Delivery Methods, Structures, and Compositions for Nasolacrimal System
有权
药物输送方法,结构和组合物用于鼻泪管系统
- 专利标题: Drug Delivery Methods, Structures, and Compositions for Nasolacrimal System
- 专利标题(中): 药物输送方法,结构和组合物用于鼻泪管系统
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申请号: US11695537申请日: 2007-04-02
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公开(公告)号: US20070269487A1公开(公告)日: 2007-11-22
- 发明人: Eugene de Juan , Cary Reich , Stephen Boyd , Hanson Gifford , Mark Deem
- 申请人: Eugene de Juan , Cary Reich , Stephen Boyd , Hanson Gifford , Mark Deem
- 申请人地址: US CA Menlo Park 94025
- 专利权人: FORSIGHT LABS, LLC
- 当前专利权人: FORSIGHT LABS, LLC
- 当前专利权人地址: US CA Menlo Park 94025
- 主分类号: A61F2/02
- IPC分类号: A61F2/02 ; A61K31/215 ; A61K38/13 ; A61P27/02 ; A61P27/06
摘要:
An implant for insertion into a punctum of a patient comprises a body. The body has a distal end, a proximal end, and an axis therebetween. The distal end of the body is insertable distally through the punctum into the canalicular lumen. The body comprises a therapeutic agent included within an agent matrix drug core. Exposure of the agent matrix to the tear fluid effects an effective therapeutic agent release into the tear fluid over a sustained period. The body has a sheath disposed over the agent matrix to inhibit release of the agent away from the proximal end. The body also has an outer surface configured to engage luminal wall tissues so as to inhibit expulsion when disposed therein. In specific embodiments, the agent matrix comprises a non-bioabsorbable polymer, for example silicone in a non-homogenous mixture with the agent.