Corneal onlays and wavefront aberration correction to enhance vision
    2.
    发明授权
    Corneal onlays and wavefront aberration correction to enhance vision 失效
    角膜镶嵌和波前像差矫正以增强视力

    公开(公告)号:US07585075B2

    公开(公告)日:2009-09-08

    申请号:US11881727

    申请日:2007-07-27

    IPC分类号: A61B3/00 A61B3/10

    摘要: Devices and methods for improving vision are described. The vision of a person can be corrected using a corneal onlay or a lens positioned between an epithelial cell layer and Bowman's membrane of the person's eye. Wavefront aberrations are measured for the person's eye or eyes, and the aberrations are used to shape the corneal onlay to provide a desired vision correction power, or to shape the person's cornea.

    摘要翻译: 描述了用于改善视力的装置和方法。 可以使用位于人眼的上皮细胞层和Bowman膜之间的角膜镶嵌物或透镜来校正人的视力。 测量人眼或眼睛的波前像差,并且使用像差来形成角膜镶嵌以提供期望的视力矫正能力,或者使人的角膜变形。

    Inserting lenses into corneal epithelial pockets to improve vision
    4.
    发明授权
    Inserting lenses into corneal epithelial pockets to improve vision 失效
    将镜片插入角膜上皮囊以改善视力

    公开(公告)号:US07828844B2

    公开(公告)日:2010-11-09

    申请号:US10661400

    申请日:2003-09-12

    IPC分类号: A61F2/14

    摘要: Methods of correcting vision are described. The methods include inserting a lens into a corneal epithelial pocket or a pocket created between a corneal epithelium of an eye of a patient and Bowman's membrane of the eye. A lens is inserted into the pocket to correct vision. Certain methods include one or more steps of cooling the corneal epithelium, and applying an aqueous liquid to the eye. The lenses that are inserted into the pocket can include collagen, including recombinant collagen, synthetic polymeric materials, and combinations thereof.

    摘要翻译: 描述矫正视力的方法。 所述方法包括将镜片插入到患者眼睛的角膜上皮和眼睛的鲍曼氏膜之间形成的角膜上皮窝或口袋内。 将镜头插入口袋以矫正视力。 某些方法包括冷却角膜上皮的一个或多个步骤,以及向眼睛施加含水液体。 插入口袋中的镜片可以包括胶原蛋白,包括重组胶原蛋白,合成聚合物材料及其组合。

    Posterior Segment Drug Delivery
    5.
    发明申请
    Posterior Segment Drug Delivery 有权
    后期药物递送

    公开(公告)号:US20100255061A1

    公开(公告)日:2010-10-07

    申请号:US12696678

    申请日:2010-01-29

    摘要: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

    摘要翻译: 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小,当耦合到多孔结构并且植入患者体内时,释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧,以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。 第一侧的每个开口可以与多个互连通道连接到第二侧的每个开口,使得当一个或多个开口被阻塞时可以基本上保持治疗剂的释放速度 ,例如当器件长时间植入时,可以使用颗粒,细胞,细菌或组织。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置许多包括可扩张的保留结构和可扩张的储存器,使得该装置可以从输送装置的内腔输送,并且在定位在患者体内时膨胀。 治疗装置可以包括当植入患者时将治疗剂注入装置中的可穿透屏障。

    Method of correcting vision using corneal onlays
    9.
    发明授权
    Method of correcting vision using corneal onlays 有权
    使用角膜镶嵌矫正视力的方法

    公开(公告)号:US09125735B2

    公开(公告)日:2015-09-08

    申请号:US12897131

    申请日:2010-10-04

    IPC分类号: A61F2/14 A61F9/00

    摘要: A corneal onlay is configured to adhere to the cornea so as to inhibit epithelial growth under the onlay. Structures can be provided on the onlay to adhere the onlay to the eye. At least one of an epithelial layer or the water inhibiting layer can be provided on or over the onlay, for example a natural epithelial layer or water inhibiting layer that inhibits, for example minimizes, water penetration into the onlay, so as to adhere the onlay to the eye with pumping of the endothelium. The water inhibiting layer may comprise a therapeutic covering positioned over the onlay to inhibit swelling of the cornea. The posterior surface of the onlay may be shaped so as to fit the anterior exposed surface of the cornea.

    摘要翻译: 角膜镶嵌被配置成粘附在角膜上,以便抑制覆盖物下的上皮生长。 可以在镶嵌上提供结构以将贴面粘附到眼睛上。 上皮层或水分抑制层中的至少一个可以设置在覆盖物上或上方,例如天然上皮层或水分抑制层,其抑制例如使水渗入到镶嵌物中的最小程度,以便粘附该覆盖层 通过泵送内皮到眼睛。 防水层可以包括定位在覆层上的治疗覆盖物,以抑制角膜的肿胀。 垫片的后表面可以被成形为适合角膜的前暴露表面。

    INTRAOCULAR, ACCOMMODATING LENS AND METHODS OF USE
    10.
    发明申请
    INTRAOCULAR, ACCOMMODATING LENS AND METHODS OF USE 有权
    内镜,镜片镜片和使用方法

    公开(公告)号:US20140135918A1

    公开(公告)日:2014-05-15

    申请号:US14161183

    申请日:2014-01-22

    IPC分类号: A61F2/16

    摘要: An intraocular lens is adapted for insertion into a capsular bag having a zonular contact region. The intraocular lens comprises a shape changing optical element and an accommodating element comprising at least one force transmitting element and a plurality of spaced apart contacting elements each adapted to contact a portion of the zonular contact region and transmit compressive displacement radially inward at an oblique angle to the optical element and configured to cooperate with at least one of the ciliary muscle of the mammalian eye, the zonules of the mammalian eye and the vitreous pressure in the eye to effect an accommodating shape and a disaccommodating shape change to the optical element.

    摘要翻译: 眼内透镜适于插入具有区域接触区域的囊袋中。 所述眼内透镜包括形状改变光学元件和容纳元件,所述容纳元件包括至少一个力传递元件和多个间隔开的接触元件,每个接触元件适于接触所述区域接触区域的一部分,并以 所述光学元件被配置为与哺乳动物眼睛的睫状肌,哺乳动物眼睛的小环和眼睛中的玻璃体压力中的至少一个配合,以实现对光学元件的适应形状和不适应的形状的变化。