发明申请
US20070281899A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 GENE
有权
用于抑制Eg5基因表达的组合物和方法
- 专利标题： COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 GENE
- 专利标题（中）： 用于抑制Eg5基因表达的组合物和方法
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申请号： US11694215申请日： 2007-03-30
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公开(公告)号： US20070281899A1公开(公告)日： 2007-12-06
- 发明人: David Bumcrot , Pamela Tan , Hans-Peter Vornlocher , Anke Geick
- 申请人： David Bumcrot , Pamela Tan , Hans-Peter Vornlocher , Anke Geick
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07H21/02 ; C12N15/09
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Eg5 gene (Eg5 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the Eg5 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Eg5 expression and the expression of the Eg5 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Eg5 gene in a cell.