Methods and devices are provided for treating multiple interval well bores. More particularly, an isolation assembly may be used to allow for zonal isolation to allow treatment of selected productive or previously producing intervals in multiple interval well bores. One example of a method for treating a multiple interval well bore includes the steps of: providing an isolation assembly comprising a liner and a plurality of swellable packers wherein the plurality of swellable packers are disposed around the liner at selected spacings; introducing the isolation assembly into the well bore; allowing at least one of the plurality of swellable packers to swell so as to provide zonal isolation of at least one of a plurality of selected intervals; establishing fluidic connectivity to the at least one of a plurality of selected intervals; and treating the at least one of a plurality of selected intervals.