发明申请
- 专利标题: Association of Protein Polymorphisms With Coronary Heart Disease
- 专利标题(中): 蛋白多态性与冠心病的关系
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申请号: US11574839申请日: 2005-08-27
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公开(公告)号: US20070292859A1公开(公告)日: 2007-12-20
- 发明人: Detlef Kozian , Heinz Goegelein , Karl-Ernst Siegler , Martina Jacobs , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
- 申请人: Detlef Kozian , Heinz Goegelein , Karl-Ernst Siegler , Martina Jacobs , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
- 申请人地址: DE Frankfurt 65929
- 专利权人: SANOFI-AVENTIS DEUTSCHLAND GMBH
- 当前专利权人: SANOFI-AVENTIS DEUTSCHLAND GMBH
- 当前专利权人地址: DE Frankfurt 65929
- 优先权: EP04021528.7 20040910
- 国际申请: PCT/EP05/09270 WO 20050827
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68 ; C07H21/00 ; C07H21/04 ; G01N33/53 ; G01N33/68 ; C07K14/00 ; C12Q1/02
摘要:
The invention concerns methods of identifying an increase in risk for coronary heart disease in an individual, wherein the presence of another amino acid than Glutaminic Acid at position 23 and/or the presence of another amino acid than Valine at position 337 in the Kir6.2 protein is determined in a sample. Moreover, probes, primers, polypeptides or polynucleotides suitable for said methods are claimed.
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