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发明申请
US20080004271A1 Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith 审中-公开
TNFalpha，PDE4和B-RAF的抑制剂，其组合物及其使用方法

Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith
摘要：
Provided herein are compounds having TNFα and/or PDE4 and/or B-RAF inhibitory activity, and compositions thereof. In particular, provided herein are compounds of the formula I: and pharmaceutically acceptable salts, solvates, hydrates, clathrates, stereoisomers, polymorphs and prodrugs thereof, wherein Ar, R1, R2, R3, R4, n and Z are as described herein. Further provided herein are methods for treating or preventing various diseases and disorders by administering to a patient one or more TNFα and/or PDE4 and/or B-RAF inhibitors. In particular, provided herein are methods for preventing or treating cancer, inflammatory disorders, cognition and memory disorders and autoimmune disorders, or one or more symptoms thereof by administering to a patient one or more TNFα and/or PDE4 and/or B-RAF inhibitors.
摘要（中）：

本文提供具有TNFα和/或PDE4和/或B-RAF抑制活性的化合物及其组合物。 特别地，本文提供了式I的化合物及其药学上可接受的盐，溶剂合物，水合物，包合物，立体异构体，多晶型物和前药，其中Ar，R 1，R 2， R S，R 3，R 4，n和Z如本文所述。 本文还提供了通过向患者施用一种或多种TNFα和/或PDE4和/或B-RAF抑制剂来治疗或预防各种疾病和病症的方法。 特别地，本文提供了通过向患者施用一种或多种TNFα和/或PDE4和/或B-RAF抑制剂来预防或治疗癌症，炎症性疾病，认知和记忆障碍和自身免疫性疾病或其一种或多种症状的方法 。

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