发明申请
- 专利标题： Inhibitors of phosphodiesterase type-IV
- 专利标题（中）： 磷酸二酯酶IV型抑制剂
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申请号： US11390491申请日： 2006-03-27
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公开(公告)号： US20080009535A1公开(公告)日： 2008-01-10
- 发明人: Sarala Balachandran , Nidhi Gupta , Nagarajan Muthukaman , Vinayak Khairnar , Sarika Ramnani , Lalit Baregama , Saswati Chakladar , Mandadapu Raghu Ramaiah , Ritu Agarwal , Sunanda Dastidar , Abhijit Ray
- 申请人： Sarala Balachandran , Nidhi Gupta , Nagarajan Muthukaman , Vinayak Khairnar , Sarika Ramnani , Lalit Baregama , Saswati Chakladar , Mandadapu Raghu Ramaiah , Ritu Agarwal , Sunanda Dastidar , Abhijit Ray
- 主分类号： A61K31/424
- IPC分类号： A61K31/424 ; A61P11/00 ; A61P11/06 ; A61P17/06 ; A61P29/00 ; A61P31/12 ; C07D261/04
摘要：
The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.
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