公开(公告)号：US20080312285A1

公开(公告)日：2008-12-18

申请号：US12065819

申请日：2006-08-30

申请人： Venkata Palle ,  Sarala Balachandran ,  Lalit Kumar Baregama ,  Saswati Chakladar ,  Sarika Ramnani ,  Nagarajan Muthukamal ,  Abhijit Ray ,  Sunanda G. Dastidar

发明人： Venkata Palle ,  Sarala Balachandran ,  Lalit Kumar Baregama ,  Saswati Chakladar ,  Sarika Ramnani ,  Nagarajan Muthukamal ,  Abhijit Ray ,  Sunanda G. Dastidar

IPC分类号： A61K31/4439 ,  C07D413/10 ,  A61K31/422 ,  A61K31/4245 ,  A61P11/06 ,  C07D413/14 ,  A61P31/18

CPC分类号： C07D413/04 ,  C07D413/14

摘要： The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors. Formula (Ia)

摘要翻译： 本发明涉及结构Ia的异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 本文公开的化合物可用于治疗CNS疾病，AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。 提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途。 式（Ia）

公开(公告)号：US20080009535A1

公开(公告)日：2008-01-10

申请号：US11390491

申请日：2006-03-27

申请人： Sarala Balachandran ,  Nidhi Gupta ,  Nagarajan Muthukaman ,  Vinayak Khairnar ,  Sarika Ramnani ,  Lalit Baregama ,  Saswati Chakladar ,  Mandadapu Raghu Ramaiah ,  Ritu Agarwal ,  Sunanda Dastidar ,  Abhijit Ray

发明人： Sarala Balachandran ,  Nidhi Gupta ,  Nagarajan Muthukaman ,  Vinayak Khairnar ,  Sarika Ramnani ,  Lalit Baregama ,  Saswati Chakladar ,  Mandadapu Raghu Ramaiah ,  Ritu Agarwal ,  Sunanda Dastidar ,  Abhijit Ray

IPC分类号： A61K31/424 ,  A61P11/00 ,  A61P11/06 ,  A61P17/06 ,  A61P29/00 ,  A61P31/12 ,  C07D261/04

CPC分类号： C07D261/20 ,  C07D413/12 ,  C07D498/10

摘要： The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.

摘要翻译： 本发明涉及异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 特别地，本文公开的化合物可用于治疗AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是在人类中。 本发明还涉及制备所公开的化合物及其药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途的方法。

公开(公告)号：US20090221566A1

公开(公告)日：2009-09-03

申请号：US12090790

申请日：2006-10-05

申请人： Venkata P. Palle ,  Sarala Balachandran ,  Sarika Ramnani ,  Abhijit Ray ,  Sunanda G. Dastidar

发明人： Venkata P. Palle ,  Sarala Balachandran ,  Sarika Ramnani ,  Abhijit Ray ,  Sunanda G. Dastidar

IPC分类号： A61K31/537 ,  C07D265/02 ,  A61K31/535 ,  A61P25/00 ,  A61P11/06 ,  A61P11/08 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10

CPC分类号： C07D265/02

摘要： The present invention relates to oxazine derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CMS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors.

摘要翻译： 本发明涉及恶嗪衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 本文公开的化合物可用于治疗CMS疾病，AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。 提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途。

公开(公告)号：US20110021473A1

公开(公告)日：2011-01-27

申请号：US12442257

申请日：2007-09-22

申请人： Sonali Rudra ,  Nidhi Gupta ,  Lalit Kumar Baregama ,  Ritu Agarwal ,  Vinayak Vasantrao Khairnar ,  Saswati Chakladar ,  Mandadapu Raghu Ramaiah ,  Nagarajan Muthukamal ,  Sarala Balachandran ,  Sarika Ramnani ,  Venkata P. Palle ,  Sunanda G. Dastidar ,  Abhijit Ray ,  Lalitha Vijaykrishan ,  Jitendra Sattigeri

发明人： Sonali Rudra ,  Nidhi Gupta ,  Lalit Kumar Baregama ,  Ritu Agarwal ,  Vinayak Vasantrao Khairnar ,  Saswati Chakladar ,  Mandadapu Raghu Ramaiah ,  Nagarajan Muthukamal ,  Sarala Balachandran ,  Sarika Ramnani ,  Venkata P. Palle ,  Sunanda G. Dastidar ,  Abhijit Ray ,  Lalitha Vijaykrishan ,  Jitendra Sattigeri

IPC分类号： A61K31/424 ,  C07D498/10 ,  C07D261/20 ,  A61K31/423 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/454 ,  A61K31/573 ,  A61P29/00 ,  A61P25/00 ,  A61P17/00 ,  A61P11/00 ,  A61P19/00 ,  A61P31/18

CPC分类号： C07D498/10 ,  C07D261/04 ,  C07D261/20

摘要： The present invention relates to catechol derivatives of formula (I), which can be used as inhibitors of phosphodiesterase (PDPI) type 4 or type 7, Compounds disclosed herein can be useful in the treatment of CNS disorders, inflammatory diseases such as, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type 4 or type 7 inhibitors.

摘要翻译： 本发明涉及式（I）的儿茶酚衍生物，其可用作4型或7型磷酸二酯酶（PDPI）的抑制剂。本文公开的化合物可用于治疗CNS疾病，炎性疾病如AIDS， 哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS），嗜酸性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎等炎症性疾病 在人类 提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为4型或7型抑制剂的磷酸二酯酶（PDE）的用途。

公开(公告)号：US07781460B2

公开(公告)日：2010-08-24

申请号：US12065819

申请日：2006-08-30

申请人： Venkata Palle ,  Sarala Balachandran ,  Lalit Kumar Baregama ,  Saswati Chakladar ,  Sarika Ramnani ,  Nagarajan Muthukamal ,  Abhijit Ray ,  Sunanda G. Dastidar

发明人： Venkata Palle ,  Sarala Balachandran ,  Lalit Kumar Baregama ,  Saswati Chakladar ,  Sarika Ramnani ,  Nagarajan Muthukamal ,  Abhijit Ray ,  Sunanda G. Dastidar

IPC分类号： A61K31/443 ,  A61K31/416 ,  A61K31/422 ,  A61K31/427 ,  C07D413/04 ,  C07D271/06 ,  C07D271/10 ,  C07D261/04

CPC分类号： C07D413/04 ,  C07D413/14

摘要： The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors.

摘要翻译： 本发明涉及结构Ia的异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 本文公开的化合物可用于治疗CNS疾病，AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。 提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途。