发明申请
US20080015213A1 Macrocyclic Aminopyridyl Beta-Secretase Inhibitors For The Treatment Of Alzheimer's Disease
有权
用于治疗阿尔茨海默病的大环氨基吡啶基β-分泌酶抑制剂
- 专利标题： Macrocyclic Aminopyridyl Beta-Secretase Inhibitors For The Treatment Of Alzheimer's Disease
- 专利标题（中）： 用于治疗阿尔茨海默病的大环氨基吡啶基β-分泌酶抑制剂
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申请号： US11791465申请日： 2005-11-18
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公开(公告)号： US20080015213A1公开(公告)日： 2008-01-17
- 发明人: Philippe Nantermet , Hemaka Rajapakse , Harold Selnick , Keith Moore
- 申请人： Philippe Nantermet , Hemaka Rajapakse , Harold Selnick , Keith Moore
- 国际申请： PCT/US05/42233 WO 20051118
- 主分类号： A61K31/4353
- IPC分类号： A61K31/4353 ; A61P25/28 ; C07D221/06 ; C07D267/00
摘要：
The present invention is directed to macrocyclic aminopyridyl compounds represented by general formula (I), which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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