发明申请
- 专利标题: Novel Artificial Rnaos Modified At The 2o-Hydroxyl Group
- 专利标题(中): 在2-羟基改性的新型人造Rnaos
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申请号: US10591291申请日: 2005-03-02
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公开(公告)号: US20080021206A1公开(公告)日: 2008-01-24
- 发明人: Mitsuo Sekine , Kohji Seio , Hisao Saneyoshi
- 申请人: Mitsuo Sekine , Kohji Seio , Hisao Saneyoshi
- 申请人地址: JP Saitama
- 专利权人: Japan Science and Technology Agency
- 当前专利权人: Japan Science and Technology Agency
- 当前专利权人地址: JP Saitama
- 优先权: JP2004-060261 20040304
- 国际申请: PCT/JP05/03459 WO 20050302
- 主分类号: C07H21/02
- IPC分类号: C07H21/02 ; C07H19/06
摘要:
The purpose of the present invention is to develop a system for efficiently constituting cyanoethyl ethers under mild conditions and probability of the ethers as functional groups for imparting specific functions and to make a contribution to the production of novel functional nucleic acids. The present invention relates to a nucleoside that is represented by the general formula (I) or a nucleotide derived therefrom: wherein X and Y may be the same as or different from each other, and are hydrogen, optionally substituted silyl group, 4-methoxytrityl group, 4,4′-dimethoxytrityl group or a group represented by the general formula (II): wherein R1 and R2 may be the same as or different from each other, representing an alkyl group having 1-7 carbon atoms such as diisopropyl, or they are united with each other to form a ring structure, R3 represents a protective group for a phosphoric acid such as 2-cyanoethyl; and B1 represents an optionally substituted pyrimidine or purine base.
公开/授权文献
- US07569685B2 Artificial RNAóS modified at the 2ó-hydroxyl group 公开/授权日:2009-08-04
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