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    Artificial RNAóS modified at the 2ó-hydroxyl group
    3.
    发明授权
    Artificial RNAóS modified at the 2ó-hydroxyl group 失效
    在2-羟基改性的人造RNA

    公开(公告)号：US07569685B2

    公开(公告)日：2009-08-04

    申请号：US10591291

    申请日：2005-03-02

    申请人： Mitsuo Sekine ,  Kohji Seio ,  Hisao Saneyoshi

    发明人： Mitsuo Sekine ,  Kohji Seio ,  Hisao Saneyoshi

    IPC分类号： C07H21/00

    CPC分类号： C07H19/067 ,  C07H19/167 ,  Y02P20/55

    摘要： The purpose of the present invention is to develop a system for efficiently constituting cyanoethyl ethers under mild conditions and probability of the ethers as functional groups for imparting specific functions and to make a contribution to the production of novel functional nucleic acids.The present invention relates to a nucleoside that is represented by the general formula (I) or a nucleotide derived therefrom: wherein X and Y may be the same as or different from each other, and are hydrogen, optionally substituted silyl group, 4-methoxytrityl group, 4,4′-dimethoxytrityl group or a group represented by the general formula (II): wherein R1 and R2 may be the same as or different from each other, representing an alkyl group having 1-7 carbon atoms such as diisopropyl, or they are united with each other to form a ring structure, R3 represents a protective group for a phosphoric acid such as 2-cyanoethyl; and B1 represents an optionally substituted pyrimidine or purine base.

    摘要翻译： 本发明的目的是开发一种在温和条件下有效构成氰乙基醚的体系，以及作为赋予特定功能的醚作为官能团并有助于新型功能性核酸生产的可能性。 本发明涉及由通式（I）表示的核苷或由其衍生的核苷酸：其中X和Y可以相同或不同，为氢，任选取代的甲硅烷基，4-甲氧基三苯甲基 基团，4,4'-二甲氧基三苯甲基或由通式（II）表示的基团：其中R 1和R 2可以彼此相同或不同，表示具有1-7个碳原子的烷基，例如二异丙基， 或者它们相互结合形成环结构，R 3表示磷酸如2-氰基乙基的保护基; 而B1代表任选取代的嘧啶或嘌呤碱。

    Novel Artificial Rnaos Modified At The 2o-Hydroxyl Group
    4.
    发明申请
    Novel Artificial Rnaos Modified At The 2o-Hydroxyl Group 失效
    在2-羟基改性的新型人造Rnaos

    公开(公告)号：US20080021206A1

    公开(公告)日：2008-01-24

    申请号：US10591291

    申请日：2005-03-02

    申请人： Mitsuo Sekine ,  Kohji Seio ,  Hisao Saneyoshi

    发明人： Mitsuo Sekine ,  Kohji Seio ,  Hisao Saneyoshi

    IPC分类号： C07H21/02 ,  C07H19/06

    CPC分类号： C07H19/067 ,  C07H19/167 ,  Y02P20/55

    摘要： The purpose of the present invention is to develop a system for efficiently constituting cyanoethyl ethers under mild conditions and probability of the ethers as functional groups for imparting specific functions and to make a contribution to the production of novel functional nucleic acids. The present invention relates to a nucleoside that is represented by the general formula (I) or a nucleotide derived therefrom: wherein X and Y may be the same as or different from each other, and are hydrogen, optionally substituted silyl group, 4-methoxytrityl group, 4,4′-dimethoxytrityl group or a group represented by the general formula (II): wherein R1 and R2 may be the same as or different from each other, representing an alkyl group having 1-7 carbon atoms such as diisopropyl, or they are united with each other to form a ring structure, R3 represents a protective group for a phosphoric acid such as 2-cyanoethyl; and B1 represents an optionally substituted pyrimidine or purine base.

    摘要翻译： 本发明的目的是开发一种在温和条件下有效构成氰乙基醚的体系，以及作为赋予特定功能的醚作为官能团并有助于新型功能性核酸生产的可能性。 本发明涉及由通式（I）表示的核苷或由其衍生的核苷酸：其中X和Y可以相同或不同，为氢，任选取代的甲硅烷基，4-甲氧基三苯甲基 基团，4,4'-二甲氧基三苯甲基或由通式（II）表示的基团：其中R 1和R 2可以彼此相同或不同，表示具有1-7个碳原子的烷基，例如二异丙基， 或者它们相互结合形成环结构，R 3表示磷酸如2-氰基乙基的保护基; 而B1代表任选取代的嘧啶或嘌呤碱。