- 专利标题： Human Receptor Proteins; Related Reagents and Methods
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申请号： US11844179申请日： 2007-08-23
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公开(公告)号： US20080025974A1公开(公告)日： 2008-01-31
- 发明人: Gerard Hardiman , Fernando Rock , J. Bazan , Robert Kastelein , Stephen Ho , Yong-Jun Liu
- 申请人： Gerard Hardiman , Fernando Rock , J. Bazan , Robert Kastelein , Stephen Ho , Yong-Jun Liu
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P37/00 ; C07H21/00 ; C07K14/00 ; C07K16/18 ; C12N5/12
摘要：
Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.