发明申请
- 专利标题： Methods for increasing cellular energy expenditure
- 专利标题（中）： 增加细胞能量消耗的方法
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申请号： US11392914申请日： 2006-03-30
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公开(公告)号： US20080031968A1公开(公告)日： 2008-02-07
- 发明人: Antonio C. Bianco , Johan Auwerx , Marcelo A. Christoffolete , Sander Houten , Brian W. Kim , Philip Reed Larsen , Mitsuhiro Watanabe
- 申请人： Antonio C. Bianco , Johan Auwerx , Marcelo A. Christoffolete , Sander Houten , Brian W. Kim , Philip Reed Larsen , Mitsuhiro Watanabe
- 申请人地址： US MA Boston
- 专利权人： The Brigham and Women's Hospital, Inc.
- 当前专利权人： The Brigham and Women's Hospital, Inc.
- 当前专利权人地址： US MA Boston
- 主分类号： A61K35/00
- IPC分类号： A61K35/00 ; C12Q1/18 ; G01N33/53 ; G01N33/567
摘要：
The present invention is directed to methods of treating a human for a variety of conditions by administering an agonist of the G protein coupled receptor TGR5. In addition, the invention includes methods for determining whether a test compound is likely to be effective in treating one of these conditions by assaying it for its ability to raise intracellular iodothyronine deiodinase levels or for its ability to bind to and activate TGR5.
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