发明申请
- 专利标题: BONE TISSUE ENGINEERING BY EX VIVO STEM CELLS ONGROWTH INTO THREE-DIMENSIONAL TRABECULAR METAL
- 专利标题(中): 骨组织工程骨髓间充质干细胞生长成三维金刚石
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申请号: US11869361申请日: 2007-10-09
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公开(公告)号: US20080033548A1公开(公告)日: 2008-02-07
- 发明人: Zou Xuenong , Haisheng Li , Cody Bunger
- 申请人: Zou Xuenong , Haisheng Li , Cody Bunger
- 申请人地址: US IN Warsaw 46580
- 专利权人: ZIMMER, INC.
- 当前专利权人: ZIMMER, INC.
- 当前专利权人地址: US IN Warsaw 46580
- 主分类号: A61F2/02
- IPC分类号: A61F2/02 ; A61B17/08 ; A61F2/28 ; C12N5/08
摘要:
Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue.