发明申请
US20080038309A1 Use of polypeptides obtained through systematic mutations of single amino acids of human and non-human Box-A of HMGB1 to prevent and/or antagonize pathologies induced by HMGB1
有权
通过HMGB1的人和非人Box-A的单个氨基酸的系统性突变获得的多肽的使用来预防和/或拮抗由HMGB1诱导的病理学
- 专利标题： Use of polypeptides obtained through systematic mutations of single amino acids of human and non-human Box-A of HMGB1 to prevent and/or antagonize pathologies induced by HMGB1
- 专利标题（中）： 通过HMGB1的人和非人Box-A的单个氨基酸的系统性突变获得的多肽的使用来预防和/或拮抗由HMGB1诱导的病理学
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申请号： US11713789申请日： 2007-03-05
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公开(公告)号： US20080038309A1公开(公告)日： 2008-02-14
- 发明人: Silvano Fumero , Luisa Bertarione Rava Rossa , Domenico Barone , Lila Drittanti , Thierry Guyon , Gilles Borrelly , Barbara Canepa , Chiara Lorenzetto
- 申请人： Silvano Fumero , Luisa Bertarione Rava Rossa , Domenico Barone , Lila Drittanti , Thierry Guyon , Gilles Borrelly , Barbara Canepa , Chiara Lorenzetto
- 申请人地址： IT Colleretto Giacosa
- 专利权人： CREABILIS THERAPEUTICS S.p.A.
- 当前专利权人： CREABILIS THERAPEUTICS S.p.A.
- 当前专利权人地址： IT Colleretto Giacosa
- 优先权： EP04425665.9 20040903
- 主分类号： A61F2/02
- IPC分类号： A61F2/02 ; A61K31/7052 ; A61K38/16 ; A61K39/395 ; A61K9/00 ; A61P17/00 ; A61P25/00 ; A61P29/00 ; A61P3/00 ; A61P31/00 ; A61P35/00 ; C07H21/00 ; C07K14/00 ; C07K2/00 ; C12N15/63
摘要：
The present invention relates to polypeptide variants of the HMGB-1 high affinity binding domain Box-A (HMGB1 Box-A) or to a biologically active fragment of HMGB1 Box-A, which are obtained through systematic mutations of single amino acids of the wild-type HMGB1 Box-A protein and which show an increased resistance to proteases and which are therefore characterized by more favourable pharmacokinetic and pharmacodynamic profiles. Moreover, the present invention concerns the use of said polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and associated with RAGE.
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