发明申请
- 专利标题： Acylaminoheteroaryl hepatitis C virus protease inhibitors
- 专利标题（中）： 酰氨基杂芳基丙型肝炎病毒蛋白酶抑制剂
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申请号： US11503502申请日： 2006-08-11
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公开(公告)号： US20080039470A1公开(公告)日： 2008-02-14
- 发明人: Deqiang Niu , Joel D. Moore , Dong Liu , Yonghua Gai , Zhigang Chen , Yat Sun Or , Zhe Wang
- 申请人： Deqiang Niu , Joel D. Moore , Dong Liu , Yonghua Gai , Zhigang Chen , Yat Sun Or , Zhe Wang
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/498 ; A61P31/14 ; C07D207/00 ; C07D241/36 ; C07D245/02
摘要：
The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
公开/授权文献
- US07605126B2 Acylaminoheteroaryl hepatitis C virus protease inhibitors 公开/授权日：2009-10-20
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