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公开(公告)号：US07605126B2
公开(公告)日：2009-10-20
申请号：US11503502
申请日：2006-08-11
申请人： Deqiang Niu , Joel D. Moore , Dong Liu , Yonghua Gai , Zhigang Chen , Yat Sun Or , Zhe Wang
发明人： Deqiang Niu , Joel D. Moore , Dong Liu , Yonghua Gai , Zhigang Chen , Yat Sun Or , Zhe Wang
CPC分类号： C07D487/04 , C07D403/14 , C07D409/14 , C07D417/14
摘要： The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式I和II的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US20080039470A1
公开(公告)日：2008-02-14
申请号：US11503502
申请日：2006-08-11
申请人： Deqiang Niu , Joel D. Moore , Dong Liu , Yonghua Gai , Zhigang Chen , Yat Sun Or , Zhe Wang
发明人： Deqiang Niu , Joel D. Moore , Dong Liu , Yonghua Gai , Zhigang Chen , Yat Sun Or , Zhe Wang
IPC分类号： A61K31/40 , A61K31/498 , A61P31/14 , C07D207/00 , C07D241/36 , C07D245/02
CPC分类号： C07D487/04 , C07D403/14 , C07D409/14 , C07D417/14
摘要： The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式I和II的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US07291602B2
公开(公告)日：2007-11-06
申请号：US11302529
申请日：2005-12-13
申请人： Datong Tang , Yonghua Gai , Ying Sun , Zhigang Chen , Yat Sun Or , Zhe Wang
发明人： Datong Tang , Yonghua Gai , Ying Sun , Zhigang Chen , Yat Sun Or , Zhe Wang
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US07517859B2
公开(公告)日：2009-04-14
申请号：US11416739
申请日：2006-05-03
申请人： Yonghua Gai , Datong Tang , Ying Sun , Zhigang Chen , Yat Sun Or , Zhe Wang
发明人： Yonghua Gai , Datong Tang , Ying Sun , Zhigang Chen , Yat Sun Or , Zhe Wang
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US20060148731A1
公开(公告)日：2006-07-06
申请号：US11302529
申请日：2005-12-13
申请人： Datong Tang , Yonghua Gai , Ying Sun , Zhigang Chen , Yat Or , Zhe Wang
发明人： Datong Tang , Yonghua Gai , Ying Sun , Zhigang Chen , Yat Or , Zhe Wang
IPC分类号： A61K31/7052 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US20060252713A1
公开(公告)日：2006-11-09
申请号：US11416739
申请日：2006-05-03
申请人： Yonghua Gai , Datong Tang , Ying Sun , Zhigang Chen , Yat Or , Zhe Wang
发明人： Yonghua Gai , Datong Tang , Ying Sun , Zhigang Chen , Yat Or , Zhe Wang
IPC分类号： A61K31/7048 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
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公开(公告)号：US06790835B1
公开(公告)日：2004-09-14
申请号：US10455219
申请日：2003-06-05
申请人： Yao-Ling Qiu , Ly Tam Phan , Tongzhu Liu , Zhigang Chen , Yat Sun Or
发明人： Yao-Ling Qiu , Ly Tam Phan , Tongzhu Liu , Zhigang Chen , Yat Sun Or
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US06765016B1
公开(公告)日：2004-07-20
申请号：US10455648
申请日：2003-06-05
申请人： Yao-Ling Qiu , Ly Tam Phan , Zhigang Chen , Tongzhu Liu , Yat Sun Or
发明人： Yao-Ling Qiu , Ly Tam Phan , Zhigang Chen , Tongzhu Liu , Yat Sun Or
IPC分类号： A61K3135
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US20140336301A1
公开(公告)日：2014-11-13
申请号：US13577043
申请日：2011-02-04
IPC分类号： C09D163/00 , C08G59/17 , C08G59/14 , C08G59/02 , C08G59/16
CPC分类号： C08G59/027 , C07D303/16 , C08G59/02 , C08G59/1438 , C08G59/1455 , C08G59/1466 , C08G59/34 , C08G59/4207 , C08G59/4215 , C08G59/4223 , C08L63/00 , C08L63/10 , C09D163/00 , C09D163/08 , C09D175/08
摘要： The invention provides highly functional epoxy resins that may be used themselves in coating formulations and applications but which may be further functionalized via ring-opening reactions of the epoxy groups yielding derivative resins with other useful functionalities. The highly functional epoxy resins are synthesized from the epoxidation of vegetable or seed oil esters of polyols having 4 or more hydroxyl groups/molecule. In one embodiment, the polyol is sucrose and the vegetable or seed oil is selected from corn oil, castor oil, soybean oil, safflower oil, sunflower oil, linseed oil, tall oil fatty acid, tung oil, vernonia oil, and mixtures thereof. Methods of making of the epoxy resin and each of its derivative resins are disclosed as are coating compositions and coated objects using each of the resins.
摘要翻译： 本发明提供高功能的环氧树脂，其可以自己用于涂料配方和应用中，但可以通过环氧基团的开环反应进一步官能化，从而产生衍生树脂与其它有用的官能团。 高功能环氧树脂由具有4个或更多个羟基/分子的多元醇的植物油或种子油酯的环氧化合成。 在一个实施方案中，多元醇是蔗糖，植物油或种子油选自玉米油，蓖麻油，大豆油，红花油，向日葵油，亚麻籽油，妥尔油脂肪酸，桐油，葵花籽油及其混合物。 公开了环氧树脂及其衍生树脂的制备方法，即涂料组合物和使用每种树脂的涂覆物体。
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公开(公告)号：US08815969B2
公开(公告)日：2014-08-26
申请号：US13362860
申请日：2012-01-31
申请人： Zhigang Chen
发明人： Zhigang Chen
IPC分类号： C08F299/04 , C08F20/20 , C09D4/02 , C08K5/103 , C08K5/1515 , C08K5/00
CPC分类号： C08K5/1515 , C08K5/0025 , C08K5/103 , C08L33/08
摘要： A novel UV-curable coating includes acrylated soybean oil, a hyperbranched acrylate, an optional adhesion promoter, and an optional renewable reactive diluent.
摘要翻译： 一种新颖的紫外线固化涂层包括丙烯酸酯化的大豆油，超支化丙烯酸酯，任选的粘合促进剂和任选的可再生的活性稀释剂。
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