The interoperable healthcare data exchange platform seamlessly links a plurality of disparate, remote applications generally representing provider systems containing electronic health records (EHRs) to enable the real-time collection, processing and centralized storage of health records at a data store, along with enabling controlled access to the centralized storage. The central health records data store receives, in real time, substantially complete electronic medical data input from multiple, disparate providers and sources of health records. The platform enable semantic normalization of the health records by converting the data in the health records to standardized message formats using a data conversion engine and mapping the converted data to standard terminologies using mapping products.