公开(公告)号：US20140200226A1

公开(公告)日：2014-07-17

申请号：US14104569

申请日：2013-12-12

Applicant: Debopam Chakrabarti ,  Amy Wright

Inventor： Debopam Chakrabarti ,  Amy Wright

IPC: C07D471/16 ,  A61K31/4178 ,  C07C50/02 ,  A61K31/122 ,  A61K31/497 ,  A61K38/05 ,  A61K31/4745 ,  A61K31/496 ,  A61K45/06 ,  A61K31/404 ,  C07D403/14 ,  C07K5/06

CPC classification number: C07D471/16 ,  A61K31/122 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/497 ,  A61K45/06 ,  C07C50/02 ,  C07D403/14 ,  Y02A50/411 ,  A61K2300/00

Abstract: Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.

Abstract translation: 本文公开了用于治疗和预防疟疾的新型组合物和方法。

公开(公告)号：US20060264499A1

公开(公告)日：2006-11-23

申请号：US11494229

申请日：2006-07-27

Applicant: Amy Wright ,  Shirley Pomponi ,  Peter McCarthy ,  Ying Chen ,  Ross Longley

Inventor： Amy Wright ,  Shirley Pomponi ,  Peter McCarthy ,  Ying Chen ,  Ross Longley

IPC: A61K31/365

CPC classification number: C07D493/18

Abstract: The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of fungal infections and control of spoilage of food, cosmetic and other consumer items.

Abstract translation: 本发明提供生物活性大环内酯化合物的新组合物，其可有利地用于阻断细胞增殖，治疗癌症，治疗真菌感染和控制食品，化妆品和其它消费品的腐败。

公开(公告)号：US20080033035A1

公开(公告)日：2008-02-07

申请号：US11890686

申请日：2007-08-06

Applicant: Amy Wright ,  John Reed ,  Jill Roberts ,  Ross Longley

Inventor： Amy Wright ,  John Reed ,  Jill Roberts ,  Ross Longley

IPC: A61K31/366 ,  A61P35/00 ,  C07D407/06

CPC classification number: C07D407/06

Abstract: The subject invention provides novel biologically active compounds that have utility for use in inhibiting cellular proliferation. Pharmaceutical compositions comprising these compounds are also provided. In a specific embodiment, the compounds and compositions of the subject invention can be used in the treatment of cancer.

Abstract translation: 本发明提供了可用于抑制细胞增殖的新型生物活性化合物。 还提供了包含这些化合物的药物组合物。 在具体实施方案中，本发明的化合物和组合物可用于治疗癌症。

公开(公告)号：US20050009901A1

公开(公告)日：2005-01-13

申请号：US10875670

申请日：2004-06-23

Applicant: Amy Wright ,  Shirley Pomponi ,  Peter McCarthy ,  Ying Chen ,  Ross Longley

Inventor： Amy Wright ,  Shirley Pomponi ,  Peter McCarthy ,  Ying Chen ,  Ross Longley

IPC: C07D493/18 ,  A61K31/365

CPC classification number: C07D493/18

Abstract: The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of fungal infections and control of spoilage of food, cosmetic and other consumer items.

Abstract translation: 本发明提供生物活性大环内酯化合物的新组合物，其可有利地用于阻断细胞增殖，治疗癌症，治疗真菌感染和控制食品，化妆品和其它消费品的腐败。

公开(公告)号：US09181251B2

公开(公告)日：2015-11-10

申请号：US14104569

申请日：2013-12-12

Applicant: Debopam Chakrabarti ,  Amy Wright

Inventor： Debopam Chakrabarti ,  Amy Wright

IPC: A61K31/497 ,  A61K31/4965 ,  A61K31/44 ,  A61K31/415 ,  A61K31/40 ,  A61K31/12 ,  C07D471/16 ,  C07D403/14 ,  A61K31/4178 ,  C07C50/02 ,  A61K31/122 ,  A61K31/4745 ,  A61K31/496 ,  A61K45/06 ,  A61K31/404

CPC classification number: C07D471/16 ,  A61K31/122 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/497 ,  A61K45/06 ,  C07C50/02 ,  C07D403/14 ,  Y02A50/411 ,  A61K2300/00

Abstract: Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.

Abstract translation: 本文公开了用于治疗和预防疟疾的新型组合物和方法。

公开(公告)号：US20080046292A1

公开(公告)日：2008-02-21

申请号：US11654024

申请日：2007-01-17

Applicant: Scott Myers ,  John Celi ,  John Quinn ,  Gale Thompson ,  Brian Kelly ,  Marshall Ruffin ,  Garret Wu ,  Shawn Roman ,  Amy Wright ,  William Tronoski ,  Andrew Truscott

Inventor： Scott Myers ,  John Celi ,  John Quinn ,  Gale Thompson ,  Brian Kelly ,  Marshall Ruffin ,  Garret Wu ,  Shawn Roman ,  Amy Wright ,  William Tronoski ,  Andrew Truscott

IPC: G06Q50/00

CPC classification number: G16H10/60 ,  G06F16/25 ,  G06F16/283 ,  G06Q50/24

Abstract: The interoperable healthcare data exchange platform seamlessly links a plurality of disparate, remote applications generally representing provider systems containing electronic health records (EHRs) to enable the real-time collection, processing and centralized storage of health records at a data store, along with enabling controlled access to the centralized storage. The central health records data store receives, in real time, substantially complete electronic medical data input from multiple, disparate providers and sources of health records. The platform enable semantic normalization of the health records by converting the data in the health records to standardized message formats using a data conversion engine and mapping the converted data to standard terminologies using mapping products.

Abstract translation: 可互操作的医疗保健数据交换平台无缝地链接多个不同的远程应用程序，通常代表包含电子健康记录（EHR）的提供者系统，以便能够在数据存储区实时收集，处理和集中存储健康记录，以及启用受控 访问集中式存储。 中央健康记录数据存储实时接收来自多个不同提供者和健康记录来源的电子医疗数据输入。 该平台通过使用数据转换引擎将健康记录中的数据转换为标准化消息格式并使用映射产品将转换的数据映射到标准术语来实现健康记录的语义规范化。

公开(公告)号：US20070203113A1

公开(公告)日：2007-08-30

申请号：US11708767

申请日：2007-02-20

Applicant: Esther Guzman ,  Jacob Johnson ,  Amy Wright

Inventor： Esther Guzman ,  Jacob Johnson ,  Amy Wright

IPC: A61K31/4745

CPC classification number: A61K31/33 ,  A61K31/44 ,  A61K31/4745 ,  A61K45/06 ,  A61K2300/00

Abstract: Manzamine compounds have been discovered to decrease cell dissociation and cell migration associated with the metastatic potential of cancer cells and a restoration of cancer cell susceptibility to agents, such as TRAIL, which can induce apoptosis. Specifically, Manzamine A has a formerly unrecognized utility in both blocking tumor cell invasion and tumor metastasis as well in restoring cancer cell susceptibility to standard chemotherapeutic agents which induce apoptosis and, therefore, has utility in treating cancer.

Abstract translation: 已经发现曼烷胺化合物减少与癌细胞的转移潜能相关的细胞解离和细胞迁移，并恢复癌细胞对可诱导细胞凋亡的药物如TRAIL的易感性。 具体来说，Manzamine A在阻断肿瘤细胞侵袭和肿瘤转移以及恢复癌细胞对诱导细胞凋亡的标准化学治疗剂的敏感性方面具有以前未被认识的用途，因此具有治疗癌症的效用。

公开(公告)号：US20050038106A1

公开(公告)日：2005-02-17

申请号：US10889925

申请日：2004-07-12

Applicant: K. Killday ,  Amy Wright ,  Shirley Pomponi ,  Ross Longley

Inventor： K. Killday ,  Amy Wright ,  Shirley Pomponi ,  Ross Longley

IPC: A61K31/35 ,  C07D309/10 ,  C07D407/06 ,  C07D45/02

CPC classification number: C07D407/06 ,  C07D309/10

Abstract: The subject invention provides novel compositions of biologically active polyketide compounds that can advantageously be used in blocking cellular proliferation and treatment of cancer.

Abstract translation: 本发明提供了可有利地用于阻断细胞增殖和治疗癌症的生物活性聚酮化合物的新组合物。