发明申请
- 专利标题： Process For The Preparation Of Enantiomerically Enriched Beta Amino Acid Derivatives
- 专利标题（中）： 对映体富含β-氨基酸衍生物的制备方法
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申请号： US11547183申请日： 2005-04-05
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公开(公告)号： US20080058522A1公开(公告)日： 2008-03-06
- 发明人: Yi Xiao , Yongkui Sun , Thorsten Rosner , Nelo Rivera , Shane Krska , Andrew Clausen , Joseph Armstrong , Felix Spindler , Christophe Malan
- 申请人： Yi Xiao , Yongkui Sun , Thorsten Rosner , Nelo Rivera , Shane Krska , Andrew Clausen , Joseph Armstrong , Felix Spindler , Christophe Malan
- 国际申请： PCT/US05/11585 WO 20050405
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07C229/28 ; C07D211/94
摘要：
The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.
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