A programmable gain amplifier (PGA) circuit includes a gain adjust circuit and a gain select circuit that are both coupled to an output of an amplifier. The gain select circuit completes feedback to the amplifier while the gain adjust circuit is arranged to boost or cut the gain of the gain selection circuit. The gain adjust circuit can be arranged as a trim adjustment to the overall gain of the PGA circuit, where a different trim adjustment can be mapped to each gain setting such as from a look-up table. In other example implementations, the PGA circuit can periodically switch between multiple gain settings using a modulation scheme such that the overall gain is blended between the various gain settings according to a duty cycle, pulse-width, or delta-sigma modulation, with a time averaging effect on the overall gain of the PGA circuit.