A phototherapy device may be used in the treatment of various skin conditions. The phototherapy device may include multi-color LEDs for emitting multiple wavelengths of light for skin treatment. Furthermore, the phototherapy device may include a control system that receives, from a user, an indication of the skin condition to be treated, and in response the phototherapy device provides the corresponding wavelengths, intensity levels, and time interval for treatment of the skin condition. The phototherapy device may comprise a clamshell structure, pen shape, facial mask, or desk lamp design.