发明申请
US20080070869A1 Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators
审中-公开
用作代谢调节剂的丙二酰辅酶A脱羧酶抑制剂
- 专利标题： Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators
- 专利标题（中）： 用作代谢调节剂的丙二酰辅酶A脱羧酶抑制剂
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申请号： US11855984申请日： 2007-09-14
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公开(公告)号： US20080070869A1公开(公告)日： 2008-03-20
- 发明人: Thomas Arrhenius , Mi Chen , Jie Fei Cheng , Yujin Huang , Alex Nadzan , Sovouthy Tith , David Wallace , Bin Liu , Masahiro Nishimoto , Gary Lopaschuk , Jason Dyck
- 申请人： Thomas Arrhenius , Mi Chen , Jie Fei Cheng , Yujin Huang , Alex Nadzan , Sovouthy Tith , David Wallace , Bin Liu , Masahiro Nishimoto , Gary Lopaschuk , Jason Dyck
- 申请人地址： JP Tokyo 115-8543
- 专利权人： CHUGAI SEIYAKU KABUSHIKI KAISHA
- 当前专利权人： CHUGAI SEIYAKU KABUSHIKI KAISHA
- 当前专利权人地址： JP Tokyo 115-8543
- 主分类号： A61K31/66
- IPC分类号： A61K31/66 ; A61K31/155 ; A61K31/185 ; A61P3/10 ; A61P9/00 ; A61P35/00 ; A61P3/04 ; A61K31/277
摘要：
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
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