Invention Application
- Patent Title: Novel Substituted Imidazole Derivative
- Patent Title (中): 新型替代咪唑衍生物
-
Application No.: US11661486Application Date: 2005-08-30
-
Publication No.: US20080070894A1Publication Date: 2008-03-20
- Inventor: Mikako Kawamura , Takashi Hashihayata , Satoshi Sunami , Tetsuya Sugimoto , Fuyuki Yamamoto , Yoshiyuki Sato , Kaori Kamijo , Morihiro Mitsuya , Yoshikazu Iwasawa , Hideya Komatani
- Applicant: Mikako Kawamura , Takashi Hashihayata , Satoshi Sunami , Tetsuya Sugimoto , Fuyuki Yamamoto , Yoshiyuki Sato , Kaori Kamijo , Morihiro Mitsuya , Yoshikazu Iwasawa , Hideya Komatani
- Priority: JP2004-251500 20040831
- International Application: PCT/JP05/16187 WO 20050830
- Main IPC: A61K31/397
- IPC: A61K31/397 ; A61K31/496 ; A61K31/497 ; A61K31/501 ; A61K31/506 ; A61K31/52 ; A61K31/5377 ; A61K31/5513 ; A61P35/00 ; C07D237/06 ; C07D239/24 ; C07D243/14 ; C07D295/00 ; C07D473/00

Abstract:
The present invention relates to a compound represented by Formula [I] or a pharmaceutically acceptable salt or ester thereof: wherein: X1, X2, X3, and X4, which may be identical or different, are each C or N, provided that none to two of X1, X2, X3, and X4 is/are N; Y is CH or N; R1, R1′, R2, R2′, R3, R3′, R4, and R4′, which may be identical or different, are each a hydrogen atom, a lower alkyl group, or the like; R5 is a hydrogen atom or a methyl group; R6 and R7, which may be identical or different, are each a hydrogen atom, a lower alkyl group, or the like; R8 and R8′, which may be identical or different, are each a hydrogen atom, a lower alkyl group, or the like; R9 is an aryl group or a heteroaryl group which may be substituted; and n is an integer from 1 to 3, and a PLK1 inhibitor or an anticancer agent containing the same.
Public/Granted literature
- US07718801B2 Substituted imidazole derivative Public/Granted day:2010-05-18
Information query