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    Substituted imidazole derivative
    1.
    发明授权
    Substituted imidazole derivative 有权
    取代的咪唑衍生物

    公开(公告)号：US07718801B2

    公开(公告)日：2010-05-18

    申请号：US11661486

    申请日：2005-08-30

    申请人： Mikako Kawamura ,  Takashi Hashihayata ,  Satoshi Sunami ,  Tetsuya Sugimoto ,  Fuyuki Yamamoto ,  Yoshiyuki Sato ,  Kaori Kamijo ,  Morihiro Mitsuya ,  Yoshikazu Iwasawa ,  Hideya Komatani

    发明人： Mikako Kawamura ,  Takashi Hashihayata ,  Satoshi Sunami ,  Tetsuya Sugimoto ,  Fuyuki Yamamoto ,  Yoshiyuki Sato ,  Kaori Kamijo ,  Morihiro Mitsuya ,  Yoshikazu Iwasawa ,  Hideya Komatani

    IPC分类号： C07D239/00 ,  C07D239/02

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： The present invention relates to a compound represented by Formula [I] or a pharmaceutically acceptable salt or ester thereof: wherein: X1, X2, X3, and X4, which may be identical or different, are each C or N, provided that none to two of X1, X2, X3, and X4 is/are N; Y is CH or N; R1, R1′, R2, R2′, R3, R3′, R4, and R4′, which may be identical or different, are each a hydrogen atom, a lower alkyl group, or the like; R5 is a hydrogen atom or a methyl group; R6 and R7, which may be identical or different, are each a hydrogen atom, a lower alkyl group, or the like; R8 and R8′, which may be identical or different, are each a hydrogen atom, a lower alkyl group, or the like; R9 is an aryl group or a heteroaryl group which may be substituted; and n is an integer from 1 to 3, and a PLK1 inhibitor or an anticancer agent containing the same.

    摘要翻译： 本发明涉及由式[I]表示的化合物或其药学上可接受的盐或酯：其中：X 1，X 2，X 3和X 4可以相同或不同，各自为C或N，条件是 X1，X2，X3和X4中的两个为N; Y是CH或N; R1，R1'，R2，R2'，R3，R3'，R4和R4'可以相同或不同，分别为氢原子，低级烷基等; R5是氢原子或甲基; R 6和R 7可以相同或不同，分别为氢原子，低级烷基等; R 8和R 8'可以相同或不同，分别为氢原子，低级烷基等; R9是可以被取代的芳基或杂芳基; n为1〜3的整数，PLK1抑制剂或含有该PLK1抑制剂的抗癌剂。