发明申请
US20080085862A1 NATRIURETIC PEPTIDE CONJUGATE USING CARRIER SUBSTANCE
审中-公开
使用载体物质的NATRIURETIC PEPTIDE CONJUGATE
- 专利标题： NATRIURETIC PEPTIDE CONJUGATE USING CARRIER SUBSTANCE
- 专利标题（中）： 使用载体物质的NATRIURETIC PEPTIDE CONJUGATE
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申请号： US11744162申请日： 2007-05-03
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公开(公告)号： US20080085862A1公开(公告)日： 2008-04-10
- 发明人: Young Kim , Dae Kim , Sung Bae , Chang Lim , Se Kwon , Gwan Lee , Dae Song , Young Kim
- 申请人： Young Kim , Dae Kim , Sung Bae , Chang Lim , Se Kwon , Gwan Lee , Dae Song , Young Kim
- 申请人地址： KR Hwaseong-si
- 专利权人： HANMI PHARM. IND. CO., LTD.
- 当前专利权人： HANMI PHARM. IND. CO., LTD.
- 当前专利权人地址： KR Hwaseong-si
- 优先权： KR10-2003-0080299 20031113
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61P9/00 ; C07K14/00
摘要：
The present invention relates to an Natriuretic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an Natriuretic peptide, a non-peptidyl polymer and a carrier substance, which are covalently linked to each other, and a use of the same. The Natriuretic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long-acting formulations of various peptide drugs.
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