发明申请
- 专利标题： CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF
- 专利标题（中）： 异恶唑及其衍生物与细胞结合分子的结合，新型异唑衍生物，制造方法及其用途
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申请号： US11850747申请日： 2007-09-06
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公开(公告)号： US20080090758A1公开(公告)日： 2008-04-17
- 发明人: Eckhard Guenther , Olaf Schaefer , Michael Teifel , Klaus Paulini
- 申请人： Eckhard Guenther , Olaf Schaefer , Michael Teifel , Klaus Paulini
- 申请人地址： DE Frankfurt 60314
- 专利权人： AETERNA ZENTARIS GmbH
- 当前专利权人： AETERNA ZENTARIS GmbH
- 当前专利权人地址： DE Frankfurt 60314
- 优先权： EP06018750.7 20060907
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61P35/00 ; C07K16/00
摘要：
The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.