Described are selectable notch filter circuits comprising at least two different notch filter capabilities, each of which is capable of filtering interference of a designated fundamental frequency and a second harmonic of the designated fundamental frequency from an electrical signal. Each of the notch filters of the circuit is specific for real time filtering of a different designated fundamental frequency and a second harmonic thereof from digitized signal data input into the circuit. The filtering capability of each filter is dictated by control logic, which uses a coefficient set specific for the designated fundamental frequency and harmonics thereof. By using different coefficient sets, different designated fundamental frequencies and at least their second harmonic frequencies can be filtered from digitized signal data input into the circuit. Because the control logic can utilize at a given time any one (or, if desired, none) of the coefficient sets available to it, different interfering fundamental frequencies can be filtered, if and as necessary, from digitized input signal data collected over time at a substantially equivalent sampling rate. Also described are devices including one or more such selectable notch filter circuits, including implantable medical devices such as implantable cardioverter/defibrillators, as well as methods of using such devices.