A method, system, and computer program product enable the selective adjustment in the size of memory pages allocated from system memory. In one embodiment, the method includes, but is not limited to, the steps of: collecting profile data (e.g., the number of Translation Lookaside Buffer (TLB) misses, the number of page faults, and the time spent by the Memory Management Unit (MMU) performing page table walks); identifying the top N active processes, where N is an integer that may be user-defined; evaluating the profile data of the top N active processes within a given time period; and in response to a determination that the profile data indicates that a threshold has been exceeded, promoting the pages used by the top N active processes to a larger page size and updating the Page Table Entries (PTEs) accordingly.