发明申请
US20080114007A1 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE
审中-公开
作为C-FMS激酶的抑制剂的5-氧代-5,8-二氢吡啶并吡啶
- 专利标题: 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE
- 专利标题(中): 作为C-FMS激酶的抑制剂的5-氧代-5,8-二氢吡啶并吡啶
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申请号: US11875294申请日: 2007-10-19
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公开(公告)号: US20080114007A1公开(公告)日: 2008-05-15
- 发明人: Mark Player , William Parsons , Hui Huang , Daniel Hutta , Huaping Hu , James Rinker
- 申请人: Mark Player , William Parsons , Hui Huang , Daniel Hutta , Huaping Hu , James Rinker
- 主分类号: A61K31/519
- IPC分类号: A61K31/519 ; C07D471/04 ; C07D401/02 ; C07D401/14 ; A61P35/00 ; A61P9/00
摘要:
The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I: or a salt, stereoisomer, tautomer, crystalline, polymorph, amorphous, solvate, hydrate, ester, prodrug or metabolite form thereof, wherein A, Y, Z, R101 and R200 are described in the specification.