- 专利标题： METHOD OF TARGETING SPECIFIC CELL POPULATIONS USING CELL-BINDING AGENT MAYTANSINOID CONJUGATES LINKED VIA A NON-CLEAVABLE LINKER, SAID CONJUGATES AND METHODS OF MAKING SAID CONJUGATES
-
申请号： US11927217申请日： 2007-10-29
-
公开(公告)号： US20080114153A1公开(公告)日： 2008-05-15
- 发明人: Rita Steeves , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
- 申请人： Rita Steeves , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
- 申请人地址： US MA Cambridge
- 专利权人： IMMUNOGEN. INC.
- 当前专利权人： IMMUNOGEN. INC.
- 当前专利权人地址： US MA Cambridge
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; C07D491/14
摘要：
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
公开/授权文献
信息查询
