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公开(公告)号：US20080171856A1
公开(公告)日：2008-07-17
申请号：US11927251
申请日：2007-10-29
申请人： Rita STEEVES , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
发明人： Rita STEEVES , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
IPC分类号： C07K16/46 , C07D491/04
CPC分类号： C07K16/3092 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K2039/505 , C07K16/18 , C07K16/32 , C07K2317/24 , C07K2317/92
摘要： The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
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2.发明申请METHOD OF TARGETING SPECIFIC CELL POPULATIONS USING CELL-BINDING AGENT MAYTANSINOID CONJUGATES LINKED VIA A NON-CLEAVABLE LINKER, SAID CONJUGATES AND METHODS OF MAKING SAID CONJUGATES 有权使用细胞结合剂MAYTANSINOID连接的特异性细胞群体的方法，通过不可清除的连接子连接，所述结合体和制备结合物的方法公开(公告)号：US20080171865A1
公开(公告)日：2008-07-17
申请号：US11927235
申请日：2007-10-29
申请人： Rita Steeves , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
发明人： Rita Steeves , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
IPC分类号： C07D498/08
CPC分类号： C07K16/3092 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K2039/505 , C07K16/18 , C07K16/32 , C07K2317/24 , C07K2317/92
摘要： The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
摘要翻译： 本发明公开了一种将美登木素生物素靶向选定的细胞群体的方法，所述方法包括将怀疑含有所选细胞群的细胞群体或组织与细胞粘附剂美登木素生物碱缀合物接触，其中一种或多种美登木素生物碱共价连接到 细胞结合剂通过不可切割的接头和细胞结合剂结合所选细胞群的细胞。
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公开(公告)号：US20080114153A1
公开(公告)日：2008-05-15
申请号：US11927217
申请日：2007-10-29
申请人： Rita Steeves , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
发明人： Rita Steeves , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
IPC分类号： C07K14/705 , C07D491/14
CPC分类号： C07K16/3092 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K2039/505 , C07K16/18 , C07K16/32 , C07K2317/24 , C07K2317/92
摘要： The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
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公开(公告)号：US20080145374A1
公开(公告)日：2008-06-19
申请号：US11927314
申请日：2007-10-29
申请人： Rita STEEVES , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
发明人： Rita STEEVES , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
CPC分类号： C07K16/3092 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K2039/505 , C07K16/18 , C07K16/32 , C07K2317/24 , C07K2317/92
摘要： The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
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5.发明申请Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates 有权使用通过不可切割接头连接的细胞粘附剂美登木素生物碱结合物靶向特定细胞群的方法，所述缀合物和制备所述缀合物的方法公开(公告)号：US20050169933A1
公开(公告)日：2005-08-04
申请号：US10960602
申请日：2004-10-08
申请人： Rita Steeves , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
发明人： Rita Steeves , Robert Lutz , Ravi Chari , Hongsheng Xie , Yelena Kovtun
IPC分类号： A61K39/395 , C07K16/46 , C07D491/04
CPC分类号： C07K16/3092 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K2039/505 , C07K16/18 , C07K16/32 , C07K2317/24 , C07K2317/92
摘要： The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
摘要翻译： 本发明公开了一种将美登木素生物素靶向选定的细胞群体的方法，所述方法包括将怀疑含有所选细胞群的细胞群体或组织与细胞粘附剂美登木素生物碱缀合物接触，其中一种或多种美登木素生物碱共价连接到 细胞结合剂通过不可切割的接头和细胞结合剂结合所选细胞群的细胞。
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