发明申请
- 专利标题: Use of Amygdalin Analogues for the Treatment of Psoriasis
- 专利标题(中): 使用杏仁苷类似物治疗牛皮癣
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申请号: US11754917申请日: 2007-05-29
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公开(公告)号: US20080125378A1公开(公告)日: 2008-05-29
- 发明人: Juan Jesus Perez Gonzalez , Amadeu Llebaria Soldevilla , Carmen Lagunas Arnal , Andres Fernandez Garcia
- 申请人: Juan Jesus Perez Gonzalez , Amadeu Llebaria Soldevilla , Carmen Lagunas Arnal , Andres Fernandez Garcia
- 申请人地址: ES Barcelona
- 专利权人: UNIVERSITAT POLITECNICA DE CATALUNYA
- 当前专利权人: UNIVERSITAT POLITECNICA DE CATALUNYA
- 当前专利权人地址: ES Barcelona
- 优先权: ESP200402912 20041129; ESPCT/ES2005/000641 20051125
- 主分类号: A61K31/7028
- IPC分类号: A61K31/7028 ; A61P17/06 ; A61P37/00
摘要:
The compounds of formula (1), wherein n is an integer from 0 to 4; R1 is a radical selected from the group consisting of H, CH3, CH2-CH3, C(CH3)3, COOH, CONH2 and C=CH; R2, R3, R4 and R5 are radicals independently selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkoxyl and (C1-C4)-alkyl; and R6 is a radical selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkoxyl, (C1-C4)-alkyl, R7, CH=CH-R7 and O-CH2-R7; wherein R7 is phenyl or phenyl mono- or independently di-substituted with F, Cl, Br, (C1-C3)-alkoxyl or (C1-C4)-alkyl, exhibit a similar chemotactic index to that of amygdalin (natural product whose chemotaxis profile is similar to that of peptide T) and, consequently, are useful for treating inflammatory and/or allergic dermatophathies, such as psoriasis, and are especially much less toxic than amygdalin.
公开/授权文献
- US07956039B2 Use of amygdalin analogues for the treatment of psoriasis 公开/授权日:2011-06-07
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