公开(公告)号：US20110028410A9

公开(公告)日：2011-02-03

申请号：US11754917

申请日：2007-05-29

申请人： Juan Jesus Perez Gonzalez ,  Amadeu Llebaria Soldevilla ,  Carmen Lagunas Arnal ,  Andres Fernandez Garcia

发明人： Juan Jesus Perez Gonzalez ,  Amadeu Llebaria Soldevilla ,  Carmen Lagunas Arnal ,  Andres Fernandez Garcia

IPC分类号： A61K31/7028 ,  A61P17/06 ,  A61P37/00

CPC分类号： A61K31/7028

摘要： The compounds of formula (1), wherein n is an integer from 0 to 4; R1 is a radical selected from the group consisting of H, CH3, CH2-CH3, C(CH3)3, COOH, CONH2 and C=CH; R2, R3, R4 and R5 are radicals independently selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkoxyl and (C1-C4)-alkyl; and R6 is a radical selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkoxyl, (C1-C4)-alkyl, R7, CH=CH-R7 and O-CH2-R7; wherein R7 is phenyl or phenyl mono- or independently di-substituted with F, Cl, Br, (C1-C3)-alkoxyl or (C1-C4)-alkyl, exhibit a similar chemotactic index to that of amygdalin (natural product whose chemotaxis profile is similar to that of peptide T) and, consequently, are useful for treating inflammatory and/or allergic dermatophathies, such as psoriasis, and are especially much less toxic than amygdalin.

摘要翻译： 式（1）的化合物，其中n为0至4的整数; R1是选自H，CH3，CH2-CH3，C（CH3）3，COOH，CONH2和C = CH的基团; R2，R3，R4和R5是独立地选自H，F，Cl，Br，（C1-C3） - 烷氧基和（C1-C4） - 烷基的基团。 并且R 6是选自H，F，Cl，Br，（C 1 -C 3） - 烷氧基，（C 1 -C 4） - 烷基，R 7，CH = CH-R 7和O-CH 2 -R 7的基团; 其中R 7是苯基或被F，Cl，Br，（C 1 -C 3） - 烷氧基或（C 1 -C 4） - 烷基单取代或独立地取代的苯基，表现出与杏仁体相似的趋化指数（趋化性 特征与肽T相似），因此可用于治疗炎症和/或过敏性皮肤病，如牛皮癣，并且特别是比杏仁苷毒性低得多。

公开(公告)号：US20080125378A1

公开(公告)日：2008-05-29

申请号：US11754917

申请日：2007-05-29

申请人： Juan Jesus Perez Gonzalez ,  Amadeu Llebaria Soldevilla ,  Carmen Lagunas Arnal ,  Andres Fernandez Garcia

发明人： Juan Jesus Perez Gonzalez ,  Amadeu Llebaria Soldevilla ,  Carmen Lagunas Arnal ,  Andres Fernandez Garcia

IPC分类号： A61K31/7028 ,  A61P17/06 ,  A61P37/00

CPC分类号： A61K31/7028

摘要： The compounds of formula (1), wherein n is an integer from 0 to 4; R1 is a radical selected from the group consisting of H, CH3, CH2-CH3, C(CH3)3, COOH, CONH2 and C=CH; R2, R3, R4 and R5 are radicals independently selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkoxyl and (C1-C4)-alkyl; and R6 is a radical selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkoxyl, (C1-C4)-alkyl, R7, CH=CH-R7 and O-CH2-R7; wherein R7 is phenyl or phenyl mono- or independently di-substituted with F, Cl, Br, (C1-C3)-alkoxyl or (C1-C4)-alkyl, exhibit a similar chemotactic index to that of amygdalin (natural product whose chemotaxis profile is similar to that of peptide T) and, consequently, are useful for treating inflammatory and/or allergic dermatophathies, such as psoriasis, and are especially much less toxic than amygdalin.

摘要翻译： 式（1）的化合物，其中n为0至4的整数; R 1是选自H，CH 3，CH 2 -CH 3，C（CH 3） 3 CO 3，COOH，CONH 2和C = CH; R 2，R 3，R 4和R 5是独立地选自H，F，Cl，Br，（C 1 -C 3 - ） - 烷氧基和（C - 烷基; - C 1 -C 4烷基; 并且R 6是选自H，F，Cl，Br，（C 1 -C 3 - ） - 烷氧基，（C 1 -C 3 - C 1 -C 4烷基，R 7，CH = CH-R 7和O-CH 2 -R 7; 其中R 7是苯基或被F，Cl，Br，（C 1 -C 3 -C 3） - 烷氧基单独或独立地二取代的苯基或（C 1） 表现出与杏仁体相似的趋化指数（趋化性状与肽T相似的天然产物），因此可用于治疗炎症 和/或过敏性皮肤病，例如牛皮癣，并且特别是比杏仁渣毒性低得多。