The invention relates to a system and a method for the guidance of a catheter (20) with an electrode (21) in an electrophysiological procedure. A sequence of images (I1, . . . Ik, . . . ) of the catheter (20) and of a resting reference catheter (30) is generated with an X-ray device (10) and stored together with the associated electrographic recordings from the electrodes (21, 31). A reference image (Ik) may then be selected from said sequence that corresponds to a desired electrographic pattern (Ek). In a next step, the positions (T, R) of the catheters (20, 30) are localized on the reference image (Ik), wherein the position (R) of the reference catheter (30) can be identified with the position of this catheter (30) on an actual image (I). Thus it is possible to determine on the actual image also a target position (T′ for the catheter (20) that corresponds to the position (T) of this catheter (20) on the reference image (Ik). Said target position (T) may finally be indicated on a monitor (60) to assist the guidance of the catheter (20) to a desired location.